Life cycle stages synthesis

The ECO method was developed to aid environmental impact and cost optimisation of chemical synthesis pathways or processes suitable for the research and development (R D) stage. In order to represent terms of ecological as well as economic sustainability, three objective functions which incorporate (i) energy demand (EF), (ii) risks concerning human health and the environment (EHF) and (iii) costs (CE), were defined. Their calculation follows the life cycle approach and is based on the data available already in R D. Because the application of a comprehensive LCA is both, too complex and based on data which are partially not available at the R D stage, the determination of the three objective functions is based on the SLCA approach extended by economic issues. The key objectives are introduced below. 

Phases in the life cycle of a typical eukaryotic cell. The cell cycle is divided into the resting stage (Go), the prereplication stage (G,), the synthesis or replication stage (S), the postreplication stage (G2), and the mitotic stage (M). 

Gero, A. M., Brown, G. V., and O Sullivan, W. J. (1984). Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum, f. Parasitol. 70,536-541. 

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