Library registration

Copyright Deposit. The law requires that copies of every pubHshed work be submitted to the United States Copyright Office, which is a branch of the Library of Congress. The purpose of this requirement is to stock the shelves of the Hbrary. This requirement is usually satisfied as part of the registration process failure to make deposit may ultimately lead to a fine, but will not affect the existence of the copyright. 

The United States Copyright Office furnishes a wide variety of circulars and pubHcations on all aspects of copyright, as well as registration forms. AH may be obtained from the United States Copyright Office, Library of Congress, Washington, D.C., 20559. 

One of the quickest and most comprehensive ways to find academic studies in both English and other languages is to use PubMed, maintained by the National Library of Medicine.5 The advantage of PubMed over previously mentioned sources is that it covers a greater number of domestic and foreign references. It is also free to use. If the publisher has a Web site that offers full text of its journals, PubMed will provide links to that site, as well as to sites offering other related data. User registration, a subscription fee, or some other type of fee may be required to access the full text of articles in some journals. 

Service-oriented architecture (SOA) is a hot topic these days and is considered by many people to be the enterprise computing framework of the future. In SOA, each software unit runs on a piece of hardware as a service that can be called by many different consumers. For example, a compound registration service can be called by a library enumeration tool and a chemistry e-notebook to fulfill compound registration tasks. The most popular SOA is Web services that are based on HTTP and XML or SOAP standards although SOA as a concept has existed for awhile and is not limited to Web services. SOA has a lot of advantages, the most important of which is code reuse and improved productivity. However, it also presents a lot of challenges. 

A domain object model is a model that describes key domain concepts and their relationships. Many of these concepts come from tangible objects in the real world of the problem domain. In the chemical informatics space, these are the objects that chemists are dealing with on a daily basis, such as compounds, structures, notebooks, and libraries. The domain analysis model being presented here focuses on those objects that are involved in the compound registration process. 

Registration This is an abstraction that represents a compound registration transaction. A registration can be for a single compound, a group of discrete compounds, or a compound library. 

To increase productivity, a registration system should be able to register a compound library as a single transaction. Usually a compound library consists of a group of compounds that are synthesized using parallel synthesis, combinatorial chemistry, or compounds that are acquired from commercial or academic sources. From the compound registration perspective, a library can also be a group of compounds that share some common attributes such as a research project they are synthesized for, the chemist who synthesized them, the creation date, and the notebook information. 

The clients of the interface are given three options—register a single sample, register a list of samples, and register a sample library. These registrations can... 

Most corporate databases of chemical compounds (libraries) are of the 2D type. The databases are managed using software that allows fast registration of new structures, fast retrieval of previously stored compounds, and fast substructure searching. (For more information about chemical database management software, see www.mdl.com or www.daylight.com.)... 

As mentioned above, one can purchase compounds already plated in microtiter plates from any of several vendors for 10-20 per mg of sample. The compounds are distributed on 96-well plates (see Fig. 1), allowing blank columns for positive (reference compound) and/or negative (solvent) controls. The plates are now frequently shipped with electronic plate maps on computer disks. These plate maps contain relevant information on structure and vendor ID numbers. Many pharma sites are now spending the time to solvate and distribute their existing compound libraries on microtiter plates. The compound ID numbers and plate maps can easily be imported into virtually any compound registration software system. This information can be linked to data analysis packages (see below) to provide a means of integrating structure and activity data. 

A trademark is a name, symbol, and/or color (the pink color on insulation was entitled to protection and registration, see Ref. 1) placed on a product to indicate the source of origin of the product. Trademarks can be continually renewed by grants from the Federal Government and Title 15 of the U.S. Code. Although devices and libraries created in the... 

The chemical business rules of a compound registration solution define the individual identities of chemical structure representations in order to meaningfully assign a unique corporate ID to each unique structure. After applying these rules, standardized parent structures are stored in a main structure table. The (structure) records from the original compound library data file entering the system are saved into a batch table on which each batch entry is associated with its unique parent structure. All data relating to the physical compound sample remain uniquely associated with this batch entry and thus are also associated with one unique parent structure. 

Figure 11-4. Purity assessment is a critical component in the decision process by the chemist as to whether their isolated compound is of sufficient quality to be submitted for compound registration and biological testing. To facilitate automated and rapid purity assessment of compound libraries, applescripts and visual basic scripts are used. (A) Total ion current chromatogram shows two components. (B) Extracted ion chromatogram for the expected product identifies its retention time. (C) Mass spectrum observed for the expected product. (D) UV 220-nm chromatogram indicates the expected product is approximately 75% pure. (E) UV 254-nm chromatogram indicates the expected product is approximately 66% pure.

Below we briefly outline details of some of the more important chemical databases available. All these databases are commercial and require registration and payment of an annual fee to use, although in the UK the Cambridge Structural Database and REACCS are available free to the academic community as part of the Chemical Databank Service (CDS) based at Daresbury, Warrington. In general access to such databases will vary from institute to institute and as there are a wide range of different chemistry databases potentially accessible you should ask at your library for a list of those available to you. It is not possible to describe the operation of all the databases here, but you should be able to get help from your librarians or your supervisor and learn how these very powerful tools can help you. 

In fact, the special librarians have proposed a plan which would relieve inadequacies in the library school training for special librarianship. Through this plan certain library schools would concentrate on developing certain specialized courses, thus avoiding duplication of effort and encouraging the registration of a reasonable number of students in each course. 

For the past five years, the library and the Library Committee have organized an annual spring symposium on a single topic of current interest. The 1960 sub ject was market research and two weeks before the meeting date, we were forced to close registration with 250 registrants because of space limitations. 

Wordy At the time of registration, students are required to make payment of their library fees. 

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