Leukemia inhibitory factor , bone

Palmqvist P, Persson E, Conaway HH, Lerner UH (2002) IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J Immunol 169 3353-3362... 

B6. Bohic, S., Pilet, P., and Heymann, D., Effects of leukemia inhibitory factor and oncostatin M on bone mineral formed in in vitro rat bone-marrow stromal cell culture Physicochemical aspects. Biochem. Biophys. Res. Commun. 253, 506-513 (1998). 

Lagneaux L, Dehorge A, Snoeck R, et al. Human cytomegalovirus increases constitutive production of interleukin-6 and leukemia inhibitory factor by bone marrow stromal cells. Blood 1996 87 59-66. 

Thrombopoiesis is the term used to describe the process of platelet production. The bone marrow manufactures 40,000 platelets/mL of blood each day. Proliferation and differentiation of platelet precursors are thought to be primarily influenced by cytokines such as IL-6, IL-11, leukemia inhibitory factor, and perhaps most specifically, by thrombopoietin (TPO or megakaryocyte growth and development factor see Fig. 98-6). Other hematopoietins that may act in concert, producing synergistic effects include IL-3, IL-1, GM-CSF, EPO, and Scf.34 The platelet survival time is a clinical test that can estimate the rate of platelet turnover. In healthy individuals, this time is 9.5 0.6 days.36... 

Biochemical Studies The self-renewal of mES cells depends largely on LIF (leukemia inhibitory factor) and BMP (bone morphologic protein). However, SCI maintained an mES ability to self-renew for more than 10 passages in an undifferentiated/pluripotent state and showed relatively low cellular toxicity. The compound reversibly inhibited differentiation of mES cells induced by either FBS or retinoic acid treatment, and after washout SCI, mES cells were selectively induced to differentiate into neural/neuronal, cardiac muscle, and endodermal cells. 

Evans, D.B., Gerber, B. and Feyen, J.H. M. (1994) Recombinant human leukemia inhibitory factor is mitogenic for human bone-derived osteoblast-like cells. Biochem. Blophys. Res. Commun. 199 220-226. 

Lorenzo, J.A., Sousa, S.L. and Leahy, C.L. (1990) Leukemia inhibitory factor (LIF) inhibits basal bone resorption in fetal rat long bone cultures. Cytokine 2 266-271. 

Regulation of osteoblast proliferation by leukemia inhibitory factor. J. Bone Min. Res. 6 1277-1283. 

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