Kinase evolution

M20. Michelson, A. M Blake, C. C., Evans, S. T and Orkin, S. H., Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotidebinding domain. Proc. Natl. Acad. Sci. U.S.A. 82,6965-6969 (1985). 

Xian R, Nascimben L, Kaddurah-Daouk R, et al. Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyo-pathic hamsters. J Mol Cell Cardiol. Apr 1996 28(4) 755-765. 

Rosbash You could back off the specifics of PAS domains in BMAL and White Collar. The more general question is whether we are in a position to say with confidence that these things did evolve multiple times, or are there very strong molecular connectors between systems Ravi Allada and I have recently published a paper on CK2, a kinase and a new clock mutant (Lin et al 2002). CK2 is implicated in plant clocks, Neurosopora clocks and now in animal clocks. My feeling is that the jury is still out as to whether we have hit on the key common proteins or whether it is independent evolution. 

Increased expression of BCR-ABL kinase from genomic amplification BCR-ABL independent mechanisms Clonal evolution (non- BCR-ABL-dependent mechanism) o Clonal evolution o Aneuploidy... 

Gene amplification of the BCR-ABL 1 kinase may be associated with development of IM resistance. The presence of multiple copies of the BCR-ABL 1 gene in interphase nuclei can be demonstrated by fluorescence in situ hybridization (FISH) (40,42). In one series, more than half of the patients with IM resistance had evidence of clonal evolution with the development of additional chromosome abnormalities. Paired cytogenetic analyses performed at the begiiming of IM therapy and at the time of resistance demonstrated this evolution. 

Willis SG, Lange T, Demehri S et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients correlation with clonal cytogenetic evolution but not response to therapy. B/ooc/2005 106 2128-2137. 

Alcantara, C. Cervera, J. Rubio, V. Carbamate kinase can replace in vivo carbamoyl phosphate synthetase. Implications for the evolution of carbamoyl phosphate biosynthesis. FEBS Lett., 484, 261-264 (2000)... 

Suzuki, T. Nishimura, Y. Umekawa, M. Yamamoto, Y Kawamichi, H. Furukohri, T. Evolution of phosphagen kinase VII. Isolation of glycocyamine kinase from the polychaete Neanthes diversicolor and the cDNA-derived amino acid sequences of a and chains. J. Protein Chem., 18, 13-19 (1999)... 

Moreland, B. Watts, D.C. Phosphagen kinases and evolution in the echino-dermata. Nature, 214, 458-462 (1967)... 

Suzuki, T. Kawasaki, Y Furukohri, T. Evolution of phosphagen kinase. Isolation, characterization and cDNA-derived amino acid sequence of two-domain arginine kinase from the sea anemone Anthopleura japonicus. Biochem. J., 328 (Pt 1), 301-306 (1997)... 

Src is another soluble protein Tyr kinase that associates with certain receptors when they bind their ligands. Src was the first protein found to have the characteristic (P) Tyr-bincling domain that was subsequently named the Src homology (SH2) domain. Yet another example of a receptor s association with a soluble protein kinase is the Toll-like receptor (TLR4) system through which mammals detect the bacterial lipopolysaccharide (LPS), a potent toxin. We return to the Toll-like receptor system in Section 12.6, in the context of the evolution of signaling proteins. 

Although apparently derived from the bacterial two-component signaling system, the ethylene system in Arabidopsis is different in that the His kinase activity that defines component 1 in bacteria is not essential to the transduction in Arabidopsis. The genome of the cyanobacterium Anabaena encodes proteins with both an ethylene-binding domain and an active His kinase domain. It seems likely that in the course of evolution, the ethylene receptor of vascular plants was derived from that of a cyanobacterial endosymbiont, and that the bacterial His kinase became a Ser/Thr kinase in the plant. 

Lorsch, J. R., and J. W. Szostak, In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature 371 31-36, 1994. 

Haddad J. J. (2004). Mitogen-activated protein kinases and the evolution of Alzheimer s a revolutionary neurogenetic axis for therapeutic intervention Prog. Neurobiol. 73 359-377. 

Hoffmeister D, Yang J, Liu L et al (2003) Creation of the first anomeric d/l-sugar kinase by means of directed evolution. Proc Natl Acad Sci USA 100 13184—13189... 

BorkP, Sander C, Valencia A (1993) Convergent evolution of similar enzymatic function on different protein folds the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci 2 31-40... 

Durbecq, V., Legrain, C., Roovers, M., Pierard, A., and Glansdorff, N. (1997). The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus fa nos us. a missing link in the evolution of carbamoyl phosphate biosynthesis. Proc. Natl. Acad. Sci. USA, 94, 12803-12808. 

Christians, F. C., Scapozza, L., Crameri, A., Folkers, G., and Stemmer, W. P. C. (1999). Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling. Nature Biotechnol., 17. 

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