Phosphagen kinase

Suzuki, T. Nishimura, Y. Umekawa, M. Yamamoto, Y Kawamichi, H. Furukohri, T. Evolution of phosphagen kinase VII. Isolation of glycocyamine kinase from the polychaete Neanthes diversicolor and the cDNA-derived amino acid sequences of a and chains. J. Protein Chem., 18, 13-19 (1999)... 

Moreland, B. Watts, D.C. Phosphagen kinases and evolution in the echino-dermata. Nature, 214, 458-462 (1967)... 

Storey, K.B. Purification and characterization of arginine kinase from the mantle muscle of the squid, Symplectoteuthis oualaniensis. Role of the phosphagen/phosphagen kinase system in a highly aerobic muscle. Arch. Biochem. Biophys., 179, 518-526 (1977)... 

S.J. Ellington, W.R. Chapman, M.S. Expression, purification from inclusion bodies, and crystal characterization of a transition state analog complex of arginine kinase a model for studying phosphagen kinases. Protein Sci., 6, 444-449 (1997)... 

Suzuki, T. Kawasaki, Y Furukohri, T. Evolution of phosphagen kinase. Isolation, characterization and cDNA-derived amino acid sequence of two-domain arginine kinase from the sea anemone Anthopleura japonicus. Biochem. J., 328 (Pt 1), 301-306 (1997)... 

Piccinni, E. Coppellotti, O. Phosphagens in protozoa - II. Presence of phosphagen kinase in Ochromonas danica. Comp. Biochem. Physiol. B, 62, 287-289 (1979)... 

Theoreticai, Scheme for the Evoi-ution of Phosphagen Kinases Subsequent to the Duplication of an Ancestral Arginine Kinase Gene ... 

Platzer, E.G. Wang, W. Thompson, S.N. Borchardt, D.B. Arginine kinase and phosphoarginine, a functional phosphagen, in the rhabditoid nematode Steinernema carpocapsae. J. ParasitoL, 85, 603-607 (1999)... 

When a sudden demand for energy depletes ATP, the PCr reservoir is used to replenish ATP at a rate considerably faster than ATP can be synthesized by catabolic pathways. When the demand for energy slackens, ATP produced by catabolism is used to replenish the PCr reservoir by reversal of the creatine kinase reaction. Organisms in the lower phyla employ other PCr-like molecules (collectively called phosphagens) as phosphoryl reservoirs. 

During periods of rest when ATP is abundant, creatine is phos-phorylated by creatine kinase to form phosphocreatine. This reaction is especially important in muscles. When a sudden explosive burst of muscle activity occurs, phosphocreatine phosphorylates adenosine diphosphate (ADP) to generate the ATP needed for muscle contraction (Fig. 10.4). For this reason, phosphocreatine is known as a phosphagen . 

Newsholme, E. and I. Beis, Old and new ideas on the roles of phosphagens and the kinases, in Creatine and Creatine Phosphate Scientijic and Clinical Perspectives, M. A. Conway and J.E Clark, Ekis. Academic Press, San Diego, CA, 1996, pp. 3-15. 

---