Kinase classification

Selected entries from Methods in Enzymology [vol, page(s)] General Protein kinase classification, 200, 3 protein kinase catalytic domain sequence database identification of conserved features of primary structure and classification of family members,... 

Hunter, T. Protein kinase classification (1991) Methods in Enzym. 200, 3-37... 

Additional information <1, 2> (this group of enzymes is under review by NC-IUBMB, recommendation for a nomenclature system based on acceptor amino acid specificity rather than on protein substrate. In accordance with this system protein-tyrosine kinases would belong to EC 2.7.1 l.X, <1,2> [1] The present data set is restricted to a literature review and does not contain a complete description of kinases. Classification system based on kinase domain phylogeny revealing families of enzymes with related substrate specificities, <1,2> [3]) [1, 3]... 

Hunter, T. (1991). Protein kinases classification. Methods Enzymol, 200, 3-38. 

Phospholipid Kinases. Figure 2 Classification of phosphoinositide 3-kinases. 

FIGURE 8.6 Parallel pathways to transcription and the MAP kinase family. The MAP kinases can be classified into three groups, based on the identity of the intermediate residue in their dual phosphorylation motifs (TEY, TGY, or TPY). This classification also defines three distinct signal-transduction pathways indicated as the ERK, the JNK/SAPK, and the p38/HOG pathway, each having unique protein kinases acting upstream. 

The nonreceptor PTKs are a large group of signaling proteins that have diverse roles in the control of cell proliferation, differentiation, and death. Some are widely expressed others are restricted to particular tissues. Their early classification was dominated by the discovery of pp60src, to the extent that the major group of kinases were simply known as the Src family. There are at least ten known subfamilies of nonreceptor PTKs. 

Naumann, T. and Matter, H. Structural classification of protein kinases using... 

Myshkin, E. and Wang, B. Chemometrical classification of ephrin ligands and eph kinases using GRID/CPCAapproach./. Chem. Inf. Comput. Sci. 2003, 43, 1004-1010. 

Pirard, B. and Pickett, S. D. (2000) Classification of kinase inhibitors using BCUT descriptors. J. Chem. Inf. Comput. Sci. 40, 1431-1440. 

Naumann, T. and Matter, H. (2002) Structural classification of protein kinases using 3d molecular interaction field analysis of their ligand binding sites Target family landscapes../. Med. Chem. 45, 2366-2378. 

Xia, X., Maliski, E.G., Gallant, P. and Rogers, D. (2004) Classification of kinase inhibitors using a Bayesian model. Journal of Medicinal Chemistry, 47 (18), 4463-4470. 

ATP Triphosphate Chain Conformation. Much of the work in the area of ATP triphosphate chain conformation has been performed by Cleland and co-workers (14--16). Their studies on metal(III)ATP interactions with kinases have led to the classification of kinases according to the stereochemistry of the polyphosphate chain as it binds to the active site. For the kinases they studied (hexokinase, glycerokinase, creatine kinase, phosphofructokinase, 3-phosphoglycerate kinase, acetate kinase, arginine kinase, adenylate kinase and pyruvate kinase) it was found that B, y-bidentate chromi M(III)-ATP (CrATP) and not a,6,y-tridentate CrATP is a... 

Classification, Structure and Characteristics of Ser/Thr-specific Protein Kinases... 

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