Classification, protein kinases

Selected entries from Methods in Enzymology [vol, page(s)] General Protein kinase classification, 200, 3 protein kinase catalytic domain sequence database identification of conserved features of primary structure and classification of family members,... 

Hunter, T. Protein kinase classification (1991) Methods in Enzym. 200, 3-37... 

Hunter, T. (1991). Protein kinases classification. Methods Enzymol, 200, 3-38. 

FIGURE 8.6 Parallel pathways to transcription and the MAP kinase family. The MAP kinases can be classified into three groups, based on the identity of the intermediate residue in their dual phosphorylation motifs (TEY, TGY, or TPY). This classification also defines three distinct signal-transduction pathways indicated as the ERK, the JNK/SAPK, and the p38/HOG pathway, each having unique protein kinases acting upstream. 

Naumann, T. and Matter, H. Structural classification of protein kinases using... 

Naumann, T. and Matter, H. (2002) Structural classification of protein kinases using 3d molecular interaction field analysis of their ligand binding sites Target family landscapes../. Med. Chem. 45, 2366-2378. 

Classification, Structure and Characteristics of Ser/Thr-specific Protein Kinases... 

Hanks SK, Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily kinase (catalytic) domain structure and classification. FASEB J 9 576-596... 

At present there are >100 protein kinase-inhibitor structures in publidy available structural databases which span 28 kinases and a variety of inhibitor structural classes. Based upon an analysis of these data a classification of ATP binding regions has been proposed by Traxler and Furet [59] and Bower (personal communication from Michael J. Bower, December 1999). In the subsequent discussion a slightly modified version of this classification will be used to organize the trends seen across kinases and inhibitor dasses (see Fig. 2.2). In the Traxler model, five sites were proposed of which three (adenine, sugar and phosphate-binding sites) can be directly related to ATP and two additional lipophilic sites which lay outside of the region occupied by ATP. In the Bower model, an additional polar site on the surface of the protein was proposed. 

Propylthiouracil, 736 Prospective study, 964 Prostaglandin F, 646 Prostaglandin II2 fPGHi), 645 Prostaglandin receptors, 646 Prostaglandins, 533, 642-643 biosynthesis, 400 classification, 645 colon cancer and, 912 conversion of arachidonic acid lo, 644-645 function, 646 Proteases, 60,63,88 action, 123-124, 444 bloixl clotting, 530-531 ca]duin>activated, 793 Protein C, 524,535 Protein deficiency, 116 Proiein density, 422 Protein efficiency ratio (PER), 469 71 Protein lunase B, 792 Protein kinase C, 786,793 Protein kinases, 54,161, IflS Protein nutrition, 458-459, 475 AIDS and. 480... 

Kuhn, D., Weskamp, N., Hullermeier, E., and Klebe, G. (2007) Functional classification of protein kinase binding sites using Cavbase. ChemMedChem 2, 1432-1447. 

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