Kidney oxidative damage

CotteriU, L.A., Gower, J.D., Fuller, B.J. and Green, C.J. (1989a). Oxidative damage to kidney membranes during cold ischaemiaxvidence of a role for calcium. Transplantation 48, 745-751. 

The effects of antioxidants on protein oxidation were also studied in animal experiments. Barja et al. [73] demonstrated that feeding guinea pigs with vitamin C decreased endogenous protein oxidative damage in the liver. Administration of the mixture of antioxidants containing Trolox C, ascorbic palmitate, acetylcysteine, (3-carotene, ubiquinones 9 and 10, and (+)-catechin in addition to vitamin E and selenium to rats inhibited heme protein oxidation of kidney homogenates more efficiently than vitamin E + selenium [74]. 

Several diaryl teUurides exhibit protection against TBH-induced cell death in lung fibroblast cultures. Besides, the same compounds prevent leucocyte-mediated cell damage in Caco-2 cells and protect rat kidney tissue against oxidative damage caused by anoxia and reoxygenation. 

LED, lowest effeetive dose ElID, highest ineffeetive dose in-vitro tests, J,g/mL in-vivo tests, mg/kg bw/day po, oral ip, intraperitoneal d, day w, week y, year se, subeutaneous No oxidative damage in kidney DNA Positive if followed by 5 h 0.16 aM 12-O-tetradeeanoylphorbol 13-aeetate... 

Di(2-ethylhexyl) adipate did not bind covalently to mouse liver DNA in vivo. One report showed evidence of oxidative damage in rat liver DNA in vivo but not in rat kidney DNA. A weak dominant lethal effect has been reported in male mice. Analyses of mouse bone marrow after treatment with di(2-ethylhexyl) adipate in vivo found no induction of micronuclei in one study and no induction of chromosomal aberrations in one study. Urine from rats treated with di(2-ethylhexyl) adipate by gavage was not mutagenic to Salmonella typhimurium. 

Tanaka, T., Nishiyama, Y., Okada, K., Hirota, K., Matsui, M., Yodoi, J., Hiai, H., and Toyokuni, S. 1997. Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney independence of tubular necrosis and sulfhydryl depletion. Lab. Invest. 77 145-155. 

In animals melatonin (39,40) or 1-carnitine (41) protected the kidneys against oxidative damage and the nephrotoxic effect of gentamicin. 

Lee SH, Yoon YC, Jang YY, Song JH, Han ES, Lee CS. Effect of iron and ascorbate on cyclosporine-induced oxidative damage of kidney mitochondria and microsomes. Pharmacol Res 2001 43 161-171. 

Saravanan, N., and N. Nalini. 2007b. Impact of Hemidesmus indicus R.Br. extract on ethanol-mediated oxidative damage in rat kidney. Redox Rep. 12(5) 229-235. 

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