Hemidesmus indicus

Mandal S, Das PC, Joshi PC, Chatterjee A (1991) Hemidesminine - A New Coumarino-lignoid from Hemidesmus indicus R. Br. Indian J Chem Sect B 30 712 Das PC, Joshi PC, Mandal S, Das A, Chatterjee A (1992) New Coumarinolignoids from Hemidesmus indicus R. Br. Indian J Chem Sect B 31 342... 

Grape seed polyphenolic extracts Gynostemma pentaphyllum Gypenosides Hemidesmus indicus 2 -Hydroxy-4 -methoxybenzaldehyde Hesperidin... 

Kundu A, Mitra A (2013) Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. Plant Foods Hum Nutr 68 247-253... 

No information on the safety of Hemidesmus indicus in pregnancy or lactation was identified in the scientific or traditional literature. Although this review did not identify any concerns for use while pregnant or nursing, safety has not been conclusively established. 

An ethanol extract of Hemidesmus indicus was found to reduce the toxicity of gentamicin to hair cells in organotypic cultures without affecting the uptake of gentamicin. The effective concentrations ranged from 25 to 100 fig/ml (Previati et al. 2007). 

In sheep red blood cells, an ethanol extract of Hemidesmus indicus was found to suppress cell-mediated and humoral components of the immune system (Atal et al. 1986). 

An aqueous extract of Hemidesmus indicus inhibited TNF-a and interleukin-8 in human peripheral blood mononuclear cells (Jain and Basal 2003). 

No information on the safety of Hemidesmus indicus during pregnancy or lactation was identified. 

In rats fed diets containing 25% Hemidesmus indicus for 14 days, diffuse hydropic degeneration and focal hepatocellular necrosis were observed in the livers (Arseculeratne et al. 1985). Conversely, a number of studies have demonstrated a hepatoprotective effect of alcohol extracts of Hemidesmus indicus administered at doses of 100 to 500 mg/kg for up to 30 days (Baheti et al. 2006 Prabakan et al. 2000 Saravanan and Nalini 2007a, 2007b, 2007c, 2008). 

Prabakan, M., R. Anandan, and T. Devaki. 2000. Protective effect of Hemidesmus indicus against rifampicin and isoniazid-induced hepatotoxicity in rats. Fitoterapia 71(l) 55-59. 

Previati, M., E. Gorbacella, L. Astolfl, et al. 2007. Ethanolic extract from Hemidesmus indicus (Linn) displays otoprotectant activities on organotypic cultures without interfering on gentamicin uptake. /. Chem. Neuroanat. 34(3-4) 128-133. 

Saravanan, N., and N. Nalini. 2007a. Antioxidant effect of Hemidesmus indicus on ethanol-induced hepatotoxicity in rats. /. Med. Food. 10(4) 675-682. 

Chakraborty D, Sircar D, Mitra A (2008) Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus. J Plant Physiol 165 1033-1040... 

Hemidesmus indicus R. Br. (Family Ascle-pidaceae) is reported to be a widespread adulterant to commercial supplies of sarsaparilla, which is easily distinguished organoleptically by its strong vaniUa fragrance."... 

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