Janus

Janus Green B (3-dimethylamino-7-[4-dimethylaminoazo]-5-phenylphenazonium chloride) [2869-83-2] M 511.1, m >200 . Dissolves in H2O to give a bluish violet soln which... 

Janus Red B 3-[(2-hydroxy-l-naphtholenyl)azo-2-methylphenylazo]A, Af,Af-trimethyl-benzenaminium chloride [2636-31-9] M 460.0. Crystd from Et0H/H20 (1 1 v/v) and dry in vacuum. Store in a dark bottle. 

Table 17.3 Amino acid sequences of domain Bl, the designed protein Janus, and Rop...

A gene encoding this sequence was synthesized and the corresponding protein, called Janus, was expressed, purified, and characterized. The atomic structure of this protein has not been determined at the time of writing but circular dichroic and NMR spectra show very clear differences from B1 and equally clear similarities to Rop. The protein is a dimer in solution like Rop and thermodynamic data indicate that it is a stably folded protein and not a molten globule fold like several other designed proteins. 

These results indicate that is it possible to change the fold of a protein by changing a restricted set of residues. They also confirm the validity of the rules for stability of helical folds that have been obtained by analysis of experimentally determined protein structures. One obvious impliction of this work is that it might be possible, by just changing a few residues in Janus, to design a mutant that flip-flops between a helical and p sheet structures. Such a polypeptide would be a very interesting model system for prions and other amyloid proteins. 

Wastewater Treatment Engineering Bureau of Land Water Quality Last update 03/12/01. Wastewater Treatment Engineering, Technieal Assistance and Pollution Prevention. Waste Treatment Go to the following web site http //janus.state.me.us/dep/blwq/engin.htm. 

FIGURE 5.37 Janus faces of the biotransfbrmation of xenobiotics. On one hand metabolism leads to inactivation and elimination of xenobiotics, but on the other hand many metabolites are reactive and may cause deleterious effects by binding to DNA, proteins, and other macromolecules. 

Changelian PS, Flanagan ME, Ball DJ et al (2003) Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 302 875-878... 

Forstermann U (2006) Janus-faced role of endothelial NO synthase in vascular disease - Uncoupling of NADPH oxidation from NO synthesis and its pharmacological reversal. Biol Chem 387 1521-1533... 

Cytokine receptors that couple to the JAK-STAT Pathway decode the signaling though hematopoietic cytokines (erythropoietin, thrombopoietin, colony-stimulating factors), prolactin, growth hormone, the a-, (3- and y- interferons, and a number of immunomodulatory interleukins [3], They form homodimetic or heterodimeric receptor complexes, which after ligandbinding recruit and activate isotypes of Janus kinases (JAKs). Activated JAKs in turn... 

The Pretiosa Margarita Novella was first published by Janus Lacinius in Venice in 1546. See folios 1 If (introduction). 

Petrus Bonus Ferrarensis, Pretiosa Margarita NomUa (Venice Janus Lacinius, 1546), there is no pagination for the illustrations. 

Dobbs, Betty Jo Teeter, The Janus Faces of Genius (Cambridge Cambridge University Press, 1991). 

The alchemist reconfigures the skeleton in the tomb, Bonus of Ferrara, Pretiosa Margarita Novella (Venice Janus Lacinius, 1546, n. p.). With the permission of the British Library,... 

HO s 0, WOO J L, LEUNG s s, SHAM A L, LAM T H and JANUS E D (2000) Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population. JNutr. 130 (10) 2590-93. 

Janus C. (1988). The development of responses to naturally occurring odors in Spiny Mice, Acomys cahirinus. Anim Behav 36, 1400-1406. 

Janus C. and Holman S. (1989). Development of sex differences in the response of Spiny Mouse pups to adult male odors. Physiol Behav 46, 895-900. 

Kenning M. Anderson Kaiser Aziz Callum G. Fraser Galal Ghourab Walter G. Guder Carmel J. Hillyard Kwang-Jen Hsiao E. D. Janus Gerard Nowacki... 

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