Janus dendrimers

Percec, V. Wilson, D.A. Leowanawat, R Wilson, C.J. Hughes, A.D. Kaucher, M.S. Hammer, D.A. et al. Self-assemhly of janus dendrimers into uniform dendrimersomes and other complex architectures. Science 2010,328 (5981), 1009-1014. 

Percec et al. [41,42] studied and reviewed various complex self-assembled structures in detail that can be obtained from dendritic molecules. Especially multicompartment capsules obtained by the self-assembly of a library of amphiphilic Janus-type dendrimers are impressive. The chemical linkage of two dissimilar dendritic building blocks results in Janus dendrimers and produces a break in the spherical symmetry characteristic to dendrimers. Consequently, these stmctures spontaneously promote the self-assembly upon injection of its ethanol solution to form stable unilamellar vesicular nanostructures and other complex architectures (Eig. 6.17). Dendriniersom.es... 

Dendrimersomes have been of recent interest for their stable, size-controllable, and self-assembled unilamellar vesicles of amphiphilic Janus dendrimers in water. [41,13] Compared to liposomes and polymersomes, dendrimersomes... 

Self-Assembly of Amphiphilic Janus Dendrimers into Monodisperse and Stable... 

Polymersomes are stable in time but poly disperse and require fractionation. In addition, they are generated from block copolymers that are not always biologically compatible and nontoxic. One day, Dan Hammer challenged our library approach as a potential tool to solve the problem of vesicles. We S3mthesized 11 libraries of the simplest possible amphiphilic Janus dendrimers and, to our surprise, most of them self-assembled, by simple injection in water of their ethanol or THF solutions, into stable and monodisperse vesicles that were named dendrimersomes [128]. 

Figure 13 shows an example of an amphiphilic Janus dendrimer library containing 13 molecules (Fig. 13a), the cryo-TEM of the self-assembled monodisperse dendrimersomes (Fig. 13b), and the confocal microscopy photo of a giant... 

Fig. 13 An example of library of amphiphilic Janus dendrimer (a), the cryo-TEM of the corresponding monodisperse dendrimersomes (b), and confocal microscopy image of a giant dendrimersome containing hydrophobic (red, outer ring) and hydrophilic (green, inner core) dyes (c). Reproduced with permission from [128]. Copyright 2010 American Association for the Advancement of Science...

Peterca, M., Percec, V., Leowanawat, P. and Berlin, A. (2011). Predicting the size and properties of dendrimersomes from the lamellar structure of their amphiphilic janus dendrimers. Journal of the American Chemical Society, 133, 20507-20520. 

Percec V et al (2010) Self-assembly of Janus dendrimers into uniform dendrimtasranes and other complex architectures. Science 328(5981) 1009-1014... 

Percec V, hnam MR, Peterca M, Leowanawat P (2012) Self-organizable vesicular columns assembled Irom polymers dendronized with semifluorinated Janus dendrimers act as reverse thcmnal actuators. J Am Chem Soc 134(9) 4408-4420. doi 10.1021/ja2118267... 

Most recently. Fan s group [66] readily synthesized a series of chiral diphosphane-functionahzed Janus dendrimers (up to 16 BNIAP units, 39) by using liquid-phase organic synthesis with the third-generation Frechet-type polyether dendron as the soluble support. The ruthenium complexes of these dendritic ligands were... 

Figure 4.34 Chiral TsDPEN-functionalized Janus dendrimers for the Ru-catalyzed asymmetric transfer hydrogenation.

Figure 4.35 Chiral BINAP-functionalized Janus dendrimers for the ruthenium-catalyzed asymmetric hydrogenation.

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