Isolation technology

Free-flow powders, granules or pellets are the common product forms used in the plastic industry. Isolation of the emulsion is therefore an important part of commercial processes. The product form can have a significant effect on its ease of handling, compounding and incorporation into the matrix. It also affects the powder storage stability such as compacting tendencies. The three most common approaches to isolation are contrasted below  

Type General Composition Function/Application Refs 

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Y.-L. Wang, C. Liu, M.-S. Feng, J. Dun, K.-S. Chou, Effects of underlying films on the chemical-mechanical polishing for shallow trench isolation technology, J. Thin Solid Films, 308 309, pp. 543-549, 1997. 

Site isolation technology A method that attempts to isolate wastes and contaminated soils and sediments from their surrounding environments. Site isolation technologies include the use of barriers and clay caps to isolate landfills from contaminating surrounding groundwater, surface water, air, sediments, and soils. 

Isolator technology is required especially when processing toxic or anti-cancer products and where the operator and his environment must be protected. An automatic loading and unloading system installed in an isolator system can be CIP cleaned and can be sterilized with vaporized hydrogen peroxide (VHP) (Figure 2.74.1). 

Agalloco, J. (2006), Thinking inside the box The application of isolation technology for aseptic processing, Pharm Technol., p. S8-11. 

In the early 1980 s, dramatic Improvements in both peptide isolation technology and the instrumentation for structural characterization resulted in an avalanche of new insect neuropeptide structures. Of the 50-60 known structures, about half exhibit effects on the contractile activity of insect visceral muscle at physiological concentrations. This report describes the strategies and tactics that were utilized to successfully isolate, purify, and structurally characterize this group of insect neuropeptides. 

Oldham WG. Isolation technology for scaled MOS VLSI. lEDM Technical Digest Dec 1982. p 216-219. 

Libermann, D. Lockwood, C. McConeel-Meachen, M., et al. Barrier isolation technology, a safe and effective solution for providing pharmaceutical development facilities. Pharm. Eng. 2001, 21-30. 

The work on stilbenoids was reviewed by Gorham in 1995 [4]. Herein, we review the recent progress in the studies of stilbenoids with respect to their structure, distribution, extraction and isolation, technologies used in structure identification, synthesis and biosynthesis, and the last but not the least, bioactivities. The coverage of the new structures is from 1994 (especially those that have not been covered by Gorham [4]) to June 2006 (the references in 2006 may not be collected thoroughly as some of them might have not been included in the databases yet). 

When dealing with particularly harmful products, additional steps, such as handling the products in glove boxes or using barrier isolator technology, should be used. 

Isolators for aseptic operations work at positive pressures relative to the general environment. Up-to-date isolator technologies are most often based on containment within Aexible transparent PVC tents. Sterilization of internal surfaces is by peracetic acid or hydrogen peroxide fumigation. Positive pres-... 

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