Barrier isolators

In contrast to the exterior localization of cutin, suberin can be deposited in both external and internal tissues. External deposition occurs in the periderm of secondary roots and stems and on cotton fibers, whereas internal deposition occurs in the root endodermis and the bundle sheath of monocots. The Casparian strip of the root en-dodermis contains suberin, which produces a barrier isolating the apoplast of the root cortex from the central vascular cylinder. Suberin also produces a gas-impermeable barrier between the bundle sheath and mesophyll cells in C4 plants. The bark of trees contains periderm-derived cork cells that have a high suberin content. 

Sweeney, M. Davenport, S. Edwards, L. Validation Issues for a Product Barrier/Isolator Sterile Liquid Filling System in a Controlled Environment, Proceedings of PDA/ISPE Conference on Advanced Barrier Technology, 1995. 

When materials presterilized in a bag or container need to be introduced in the sterile interior of a barrier isolator, contamination at the outer surface of the bag or container is a concern. Therefore continuous transfer chambers using ultraviolet (UV) radiation (sterile pass-through) have been developed to facilitate the transport of presterilized components (stoppers, bags, etc.). UV radiation has been considered as it has little or no effect on material or package integrity, no residual chemicals are formed, cycle times are short, it requires minimal utilities, and the maintenance and operational costs are low (Fig. 11). ... 

Libermann, D. Lockwood, C. McConeel-Meachen, M., et al. Barrier isolation technology, a safe and effective solution for providing pharmaceutical development facilities. Pharm. Eng. 2001, 21-30. 

Where appropriate, an impervious barrier to prevent cross-contamination between two zones, such as barrier isolators or pumped transfer of materials, should be used. 

When dealing with particularly harmful products, additional steps, such as handling the products in glove boxes or using barrier isolator technology, should be used. 

Thinking it Through Spontaneous chemical reactions are usually exothermic, but not always. Choice (A) cannot be true. The reverse reaction of an exothermic reaction must be endothermic, so choice (B) is eliminated for the same reason as choice (A). The activated complex exists at the top of the energy barrier isolating reactants and products. Energetically speaking, it is downhill from the activated complex to either reactants or products. Choice (D), is the correct answer, is always exothermic. The remaining choice, (Q, is always endothermic. ... 

Barrier Isolator [Mobile Isolation Chambers MIC1)... 

J.W. (2003). Geographic barriers isolate endemic populations of hyperthermophilic archaea. Science 301,976-978. 

Capital Avoidance Eliminate need for use of barrier isolators. 

Eliminate need for use of barrier isolator in potent product suite. Reduced need for specialized remediation of rinse water. 

An effective protection of metallic materials against high temperature oxidation is based on the protective oxide scale which acts as diffusion barrier, isolating the material from the aggressive atmosphere. The principle is simple, however its application is complex to act as a real barrier the oxide film needs to be dense and homogenous and has to cover entire... 

The use of H2O2 sterilization in biological safety cabinets and barrier isolators is a popular alternative to ethylene oxide (EtO) as a safer, more efficient decontamination method. H2O2 has long been widely used in the pharmaceutical industry. In aerospace research, H2O2 is used to sterilize artificial satellites and space probes. 

---