Isobutyl amine

The cis-fagaramide (J) was synthesized as outlined below. The required acetylenic acid (c) was prepared from piperonal (a) by the Corey s procedure.Treatment of piperonal with carbon tetrabromide, triphenylphosphine and zinc gave the bromo olefin (b) as an oil in 71% yield. The bromo olefin (b) was treated with 2 equivalents of n-butyl lithium followed by quenching with dry ice to give acetylenic acid (c) in 54% yield. Treatment of (c) with excess thionyl chloride without solvent at 50 followed by addition of isobutyl amine in benzene gave the acetylenic amide (d) as a viscous oil in 96% yield. Partial reduction of (d) gave cis-fagarmide (7 ) in 89% yield. 

Treatment of the peroxidic solutions with MnOa or lead tetraacetate resulted in the evolution of 02 up to 50% of that consumed in the photosensitized reaction and in the formation of NH3 and aldehydes.82,281 Thus, isobutyl amine (434) gave rise to isobutyraldehyde... 

In 2004, Ley et al. [45] showed a stereoselective enzymatic synthesis of cis-pellitorine [N-isobutyldeca-(2 ,4Z)-dienamide], a taste-active alkamide naturally occurring in tarragon. The reactants were ethyl ( ,Z)-2,4-decadienoate— the pear ester described before—and isobutyl amine. The reaction is catalysed by lipase type B from Candida antarctica (commercially available), which shows a remarkable selectivity towards the 2 ,4Z ester. The yield was about 80%. 

In borazine compounds having branched alkyl groups (other than t-butyl) at the N-atoms, a stepwise substitution of the (B)—H atoms in Grignard alkylation 84> is observed rather than the statistical substitution which occurs on alkylation of N-methylborazines with n-alkyl Grignard reagents 34>. It has been reported 49-85> that base dehydrochlorination of isobutylammonium trichlorophenylborate as well as that of isobutyl-amine-dichlorophenylborane results in a mixture of the trimeric and tetrameric N-isobutyl-B-phenylborazines [Eq. (20)]. 

The synthesis of darunavir (1) is shown in Scheme 12. Optically active bis-THF alcohol (-)-ll was converted to activated mixed carbonate 46 by treatment with N,N-disuccinimidyl carbonate (DSC) in the presence of triethylamine.30 For the synthesis of the hydroxyethylsulfonamide isostere, epoxide 38 was treated with isobutyl amine (47) in 2-propanol at reflux to provide the corresponding amino alcohol. Reaction of the resulting amino alcohol with p-nitrophenylsulfonyl chloride in the presence of aqueous NaHC03 afforded the sulfonamide derivative 48 in 95% yield for the two steps. This was converted to darunavir in a three-step process, involving (1) catalytic hydrogenation of nitro to an amine, (2) removal of the Boc group by exposure to trifluoroacetic acid in... 

C4H11N isobutyl amine 78-81-9 7.900E+09 54.890 5593 C5H10S thiacyclohexane 1613-51-0 8.050E+09 58.150... 

C8H19N di isobutyl amine 110-96-3 1.327E-h10 96.780 18201 C9H20 3,3,4-trimethylhexane 16747-31-2 1.387E+10 98.920... 

C4H6CI2 3,4-dichloro-1 -butene 760-23-6 3.934 3978 C4H11N isobutyl amine 78-81-9 3.230... 

This situation has been described by Pirkle et al. (13,14) for a type I CSp (J )-N-(10-undecanoyl)-a-(6,7-dimethyI-l-naphthyl)-isobutyl amine, and fora homologous series of solutes based on dinitrobenzoyl derivatives of 1-phenylalkyl amines. The experimental results indicated that two different interaction mechanisms were responsible for the formation of the solute/CSP complexes. One mechanism was based on dipole-dipole interactions that resulted in diastereomeric complexes where the (R)-solute/CSP complex was more stable, whereas the other was due to hydrogen-bonding interactions and produced a situation where the (S)-solute/CSP complex was more stable. 

Dimethylamin.—Bimeihylia—j. N—43—is a liquid below S" (40°.4P.) has an ammoniacal odor, and is quite soluble in HaO. It constitutes about 50 per cent, of the commercial triinethyl-amin, which also contains 5 to 10 per cent, of trimethylamin, the remainder being a mixture of luonomethylamin, isobutyl-amin, and propylamin. Its chloroplatinate forms long needles. 

The ami noacyl adenylate activation reactions 1-5 are competitively inhibited by the substrate-analogous amines (2-phenylethylamine,(T) pyrrolidine, isobutyl amine (7) tetramethylenedi amine, (T) and isopentyl amine, )as measured by ATP-PPi exchange experiments.The inhibition constants for these inhibitors are of similar order of magnitude as the Michaelis constants obtained for the activation of the corresponding substrate amino acids. The N-acyl derivatives of these substrates either function as inhibitors of the reactions 1-5 or are not accepted by the multienzyme (5). 

On the other hand, Nishimura and colleagues (374) obtained isobutyl amine and isoamyl amine from male mouse urine responsible for female puberty acceleration. 

Isobutanol is used as a chemical intermediate in the preparation of isobutyl esters, isobutyl amines, and in isobutylated urea or melamine-coating resins. Isobutanol is used as a solvent in coating formulations with or without the cosolvent n-butanol. Nitrocellulose lacquers use isobutanol as a latent solvent, while the alcohol is an active solvent in automotive and furniture finishes, lacquers thinners, and hot spray lacquers. 

FIGURE 8.1 Primary and secondary aliphatic amines, n-butyl amine (dashed line) and di-isobutyl amine (solid line). 

Solubility insoluble in water, 0.3M TsOH in dioxane, 10% TFA in chloroform, 5M NH3 in dioxane-water (4 1), or isobutyl-amine-methanol (1 9), or tertiary amines (EtsN, pyridine). Form Supplied in liquid commercially available. 

Microwave studies have been published for the molecules MeBS, PhBCl 2, MesNBMea, BFaCO, and EtBFg. Vibrational spectroscopy has been used to study EtBFa, B(C2F3)s, MeBFa, B-trimethylborazine, and the triphenylboron complexes of benzyl, butyl, and isobutyl amines. ... 

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