Isobutyl acetate iodide

Indenopyrene, see Indeno[l,2,3-crf pyrene l//-Indole, see Indole Indolene, see Indoline Inexit, see Lindane Inhibisol, see 1,1,1-Trichloroethane Insecticide 497, see Dieldrin Insecticide 4049, see Malathion Insectophene, see a-Endosulfan, p-Endosulfan Intox 8, see Chlordane Inverton 245, see 2,4,5-T lodomethane, see Methyl iodide IP, see Indeno[l,2,3-crf pyrene IP3, see Isoamyl alcohol Ipaner, see 2,4-D IPE, see Isopropyl ether IPH, see Phenol Ipersan, see Trifluralin Iphanon, see Camphor Isceon 11, see Trichlorofluoromethane Isceon 122, see Dichlorodifluoromethane Iscobrome, see Methyl bromide Iscobrome D, see Ethylene dibromide Isoacetophorone, see Isophorone a-Isoamylene, see 3-Methyl-l-butene Isoamyl ethanoate, see Isoamyl acetate Isoamylhydride, see 2-Methylbutane Isoamylol, see Isoamyl alcohol Isobac, see 2,4-Dichlorophenol Isobenzofuran-l,3-dione, see Phthalic anhydride 1,3-Isobenzofurandione, see Phthalic anhydride IsoBuAc, see Isobutyl acetate IsoBuBz, see Isobutylbenzene Isobutane, see 2-Methylpropane Isobutanol, see Isobutyl alcohol Isobutene, see 2-Methylpropene Isobutenyl methyl ketone, see Mesityl oxide Isobutyl carbinol, see Isoamyl alcohol Isobutylene, see 2-Methylpropene Isobutylethylene, see 4-Methyl-l-pentene Isobutyl ketone, see Diisobutyl ketone Isobutyl methyl ketone, see 4-Methyl-2-pentanone Isobutyltrimethylmethane, see 2,2,4-Trimethylpentane Isocumene, see Propylbenzene Isocyanatomethane, see Methyl isocyanate Isocyanic acid, methyl ester, see Methyl isocyanate Isocyanic acid, methylphenylene ester, see 2,4-Toluene-diisocyanate... 

Methyl ethyl ketone peroxide Methyl formate Methyl iodide Methyl isoamyl acetate Methyl isobutyl carbinol Methyl isobutyl ketone (hexone)... 

To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3-diethylamino-1 -cyclohexyl-1 -phenylpropanol-1 (2 mols) and the mixture is stirred until solution is complete. Then 500 parts (3.2 mols or 60% excess) of ethyl iodide are added. After filtration, the filtrate is diluted with an additional 300 parts of methyl isobutyl ketone and the solution is then heated at the reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the precipitated solid material is removed by filtration, washed with isopropyl acetate and dried. Approximately 111 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting material. 

Iodoform [75-47-8] M 393.7, m 119°. Crystd from MeOH, EtOH or EtOH/ethyl acetate. l-Iodo-2-methylpropane see isobutyl iodide. 

Unless otherwise noted, acetone was the solvent. b Yield of deoxyiodo-sugar derivative. 0 Yield of sodium sulfonate. Yield by determination of sodium iodide consumed. Free iodine liberated. / Acetonylacetone. Corrected for solubility of sodium sulfonate in acetone. A Acetic anhydride. Isobutyl methyl ketone. 

Use Chemicals (methyl isobutyl ketone methyl isobutyl carbinol methyl methacrylate bisphenol-A) paint, varnish, and lacquer solvent cellulose acetate, especially as spinning solvent to clean and dry parts of precision equipment solvent for potassium iodide and permanganate delusterant for cellulose acetate fibers specification testing of vulcanized rubber products. 

Cyanoethylation of ethyl phenylcyano-acetate, 30, 80 Cyanogen, 32, 31 Cyanogen iodide, 32, 29 Cyanogen iodide, complex with sodium iodide, 32, 31 N-Cyanoguanidine, 35, 69 Cyanohydrin formation, 33, 7 3-Cyano-6-isobutyl-2(l)-pyridone, 32, 34... 

MCI-186, has been developed as a medical drug for brain ischemia. The preparation of pyrazol-3-ones 57a-m was achieved by refluxing /i-keto esters 56a-m and hydrazines 2a-m in ethanol or acetic acid. /i-Keto esters 56d,e,j,l,m, which are not commercially available, were synthesized from acyl chlorides 52a,b, nitrile 53 or ethyl esters 55a,b with the appropriate reagents (Scheme 13). Ethyl 2-acetyl-3-methylbut-3-enoate 56k was prepared in 43% yield from ethyl 3-oxobutanoate 56a by first forming ethyl 3-oxobutanoate sodium salt and then treating the salt with isobutyl iodide in THF at 80 °C. 

The synthetic utility of the alkylation method was demonstrated in in the context of 7-secretase modulator 284, which has been studied as a potential treatment for Alzheimer s disease (Scheme 7.40). ° Compound 283 was prepared in two steps from commercially available (3-chloro-4-hydroxy-phenyl)acetate. Treatment of this species under the standard conditions of the method using isobutyl iodide as the alkylating agent gave the desired product 284 in 72% yield (96% based on recovered starting material) and 97% ee. 

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