Deactivated porasil

SEC chromatograms of PVA from various methods of producting using deactivated Porasil (14). (Courtesy of Waters/Millipore Corporation.)... 

The present evidence indicates that molecular weight iS an important factor in controlling the interferon-inducing property or the toxicity factor of the DVE-MA copolymer. The development of a method which would permit fractionation of the copolymer into fractions of narrow molecular weight distribution for further evaluation as an interferon inducer was the purpose of the investigation undertaken by Butler and Wu [49]. Two copolymer samples having i/j i, = 1.56 dl/g and 0.15 dl/g were subjected to fractionation as the polyelectrolyte on one 3 ft column each, in series, of Type AX, BX, CX, DX and EX Deactivated Porasil, without much success. However, by conversion of the copolymers to their dimethyl ester, it was possible to fractionate these derivatives on standard Styragel columns, and to compare the... 

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