Interferon-gamma inducing factor expression

Data from human and rodent studies have shown that IL-18 (previously referred to as interferon-gamma inducing factor, IGIF) expression can be associated with neuropathology in infection, autoimmune disease, ischemia, or closed head injury (Felderhoff-Mueser et al., 2005). IL-18 is a member of the IL-1 family of cytokines. Like IL-ip, it is synthesized as an inactive precursor protein (24 kDa) that is subsequently cleaved to the activel8 kDa protein by caspase-l(ICE) (Nhan et al.,... 

Zhong G, Fan T, Liu L (1999) Chlamydia inhibits interferon gamma-inducible major Histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J Exp Med 189 1931-1938... 

Most patients with AD have elevated serum IgE levels and increased numbers of circulating eosinophils (1). These laboratory findings are thought to result from the increased expression of T helper type 2 (Th2)-type cytokines, i.e., IL-4, IL-5, and IL-13 with a concomitant decrease in interferon-gamma (IFN-y) expression. IL-4 and IL-13 are known to act as IgE isotype-specific switch factors and induce the expression of VCAM-1, an adhesion molecule involved in the... 

Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, Schulzke JD (2000) Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 113 2085-2090 Marinaro M, Fasano A, De Magistris MT (2003) Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infect Immun 71 1897-1902... 

Bhandari, N., Enongene, E. N., Riley, R. T., Meredith, F. I., and Sharma, R. P. (2002). Temporal expression of fumonisin B(l)-induced tumor necrosis factor-alpha and interferon gamma in mice. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 131(2), 113-122. 

Stemme, S., Eager, G., and Hansson, G. K. MHC class II antigen expression in human vascular smooth muscle cells is induced by interferon-gamma and modulated by tumour necrosis factor and lymphotoxin. Immunology 69, 243-249 (1990). 

Lapinet, J. A., Scapini, P., Calzetti, F., Perez, O., and Cassatella, M. A. (2000). Gene expression and production of tumor necrosis factor alpha, interleukin-1 beta (IL-lbeta), IL-8, macrophage inflammatory protein lalpha (MIP-lalpha), MIP-lbeta, and gamma interferon-inducible protein 10 by human neutrophils stimulated with group B meningococcal outer membrane vesicles. Infect. Immun. 68, 6917-6923. 

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