Integrated process/product design/optimization

The first consideration in any design and optimization problem is to decide the boundaries of the system. A reactor can rarely be optimized without considering the upstream and downstream processes connected to it. Chapter 6 attempts to integrate the reactor design concepts of Chapters 1-5 with process economics. The goal is an optimized process design that includes the costs of product recovery, in-process recycling, and by-product disposition. The reactions are... 

Baculovirus-based protein expression in insect ceU culture represents today a ripened method for the rapid production of proteins up to pilot scale. Recent advances on all levels of the production process such as optimized expression vectors, chemically defined media, optimized nutritional and kinetic parameters as well as the design of novel cultivation systems contribute to drastically increased protein yields with concomitant reduction of process time and costs. This chapter provides a comprehensive overview on recent research and achievements on the successive steps in a protein expression process, with a focus on how to integrate these findings for achieving overall optimized performance. A case study on the production of a secreted protein illustrates the impact of the different optimization steps on the overall process yields. 

Traditionally, product development includes initial research, prototype production, design finalization, and transfer to manufacturing. Today s fast-moving market requires a product-development process that is integrated and efficient. This demands up-front planning and execution of design optimization and manufacturing platform-development activities that ensure conformance to end-product requirements. 

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