Insulin-like factor, signal

Karas, M. et ah. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells, Nutr. Cancer, 36,101, 2000. 

Karas, M., M. Danilenko, D. Fishman et al. 1997. Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells. J Biol Chem 272(26) 16514—16520. 

Lycopene and the Insulin-Like Growth Factor Signaling Pathway.450... 

There are several alternative pathways associated with the balance between proliferation and apoptosis that are affected by lycopene treatment, especially the insulin-like growth factor (IGF) signaling pathway. Another is the possibility that lycopene or one of its breakdown products has retinoid activity. Kotake-Nara et al. compared acyclo-retinoic acid, an in vitro oxidation product of lycopene, to four actively researched anticarcinogenic retinoids. Acycloretinoic acid was found to more actively reduce PC-3 and DU-145 cell viabilities (but not LNCaP) through apoptosis in a medium already containing small amounts of natural retinoids. But study concentrations were 20 pM, far above physiologically relevant lycopene concentrations, let alone the smaller concentration of one of its breakdown products. Acycloretinoic acid had a very low affinity for the retinoid X receptors (RXR) and retinoic acid receptors (RAR) receptors (Kotake-Nara et al. 2002). 

LYCOPENE AND THE INSULIN-LIKE GROWTH FACTOR SIGNALING PATHWAY... 

Lee AV, Cui X, Oesterreich S (2002) Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin Cancer Res 7(12 Suppl) 4429s... 

Li, H., Rajendran, G.K, Liu, N Ware, C., Rubin, B.P. and Gu, Y. (2007) SirTl modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice. Breast Cancer Research, 9, R1. 

Lu Y Zi X, Zhao Y et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab... 

Inhibition of Epidermal Growth Factor Receptor (EGFR)-Mediated Pathways 175 Inhibition of Insulin-like Growth Factor (IGF)-I Mediated Signal Transduction Pathway 175... 

Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H. 2004. Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res 64 8715-8722. 

Regulation of insulin/insulin-like growth factor-1 signaling... 

Zheng W. H. and Quirion R. (2004). Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival. J. Neurochem. 89 844-852. 

Karas, M., Amir, H., Fishman, D., Danilenko, M., Segal, S., Nahum, A., Koifmann, A., Giat, Y., Levy, J., and Sharoni, Y. 2000. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr. Cancer 36, 101-111. 

Azar, Z.M., M.Z. Mehdi, and A.K. Srivastava. 2007. Insulin-like growth factor type-1 receptor transactivation in vasoactive peptide and oxidant-induced signaling pathways in vascular smooth muscle cells. Can. J. Physiol. Pharmacol. 85 105-111. 

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