Insomnia caffeine

Geen tea Camellia sinensis Reduces cancer, lowers lipid levels, helps prevent dental caries, antimicrobial and anti oxidative effects Contains caffeine (may cause mild stimulant effects such as anxiety, nervousness, heart irregularities, restlessness, insomnia, and digestive irritation) Contains caffeine and should be avoided during pregnancy, by individuals with hypertension, anxiety, eating disorders, insomnia, diabetes, and ulcers. 

False. Tea, coffee and cola all contain caffeine, a mild stimulant drug. In small quantities it provides a refreshing increase in energy levels in larger quantities it can lead to headaches, anxiety, agitation, tremors and insomnia. In extreme cases it has been known to cause death. 

The importance of adenosine deaminase in the duration and intensity of sleep in humans has been noted recently (Retey et al. 2005). Animal studies suggest that sleep needs are genetically controlled, and this also seems to apply in humans. Probably, a genetic variant of adenosine deaminase, which is associated with the reduced metabolism of adenosine to inosine, specifically enhances deep sleep and slow wave activity during sleep. Thus low activity of the catabolic enzyme for adenosine results in elevated adenosine, and deep sleep. In contrast, insomnia patients could have a distinct polymorphism of more active adenosine deaminase resulting in less adenosine accumulation, insomnia, and a low threshold for anxiety. This could also explain interindividual differences in anxiety symptoms after caffeine intake in healthy volunteers. This could affect the EEG during sleep and wakefulness in a non-state-specific manner. 

Salin-Pascual R. J., Valencia-Flores M., Campos R. M., Castano A., Shiromani P. J. (2006). Caffeine challenge in insomnia patients after total sleep deprivation. Sleep Med. 7, 141-5. 

Once chronic insomnia has developed, it hardly ever spontaneously resolves without treatment or intervention. The toll of chronic insomnia can be very high and the frustration it produces may precipitate a clinical depression or an anxiety disorder. Insomnia is also associated with decreased productivity in the workplace and more frequent use of medical services. Einally, substance abuse problems may result from the inappropriate use of alcohol or sedatives to induce sleep or caffeine and other stimulants to maintain alertness during the day. 

Substance-Induced Insomnia. A variety of substances can cause or worsen sleep problems (see Table 9.2). Patients often miss the connection between the ingestion of a medication or caffeine and the onset of their insomnia, and they rarely spontaneously volunteer this information. 

The adverse effects of caffeine are a common experience to most caffeine consumers. Too much caffeine results in uncomfortable to adverse central nervous system effects, or neurotoxicity. The effects include restlessness, tension, and mild tremor or the jitters and may progress to feelings of anxiety and even fear. Regular caffeine users soon learn how to manage their caffeine consumption to maintain blood caffeine at a desirable level that produces mild stimulation without the uncomfortable neurotoxic effects. Fortunately, the half-life of caffeine is short, so that any undesirable effects soon decline. Many people also experience insomnia from caffeine consumption. Caffeine s effect on sleep varies from individual to individual. Some people can consume caffeine late in the evening and sleep well, but for other people consumption of caffeine late in the day affects sleep. It is important to understand your own individual response to caffeine. 

Estazolam (Prosom) [C-IV] [Hypnotic/Benzodiazepine] Uses Short-term management of insomnia Action Benzodiazepine Dose 1-2 mg PO qhs PRN -1- in hqjatic impair/elderly/debilitated Caution [X, -] t Effects w/ CNS d ressants Contra PRG Disp Tabs SE Somnolence, weakness, palpitations, anaphylaxis, angioedema, amnesia Interactions t Effects W7 amoxicillin, clarithromycin T effects OF diaz am, phen5rtoin, warfarin X effects W7 food X effects OF azole antifungals, digoxin EMS Use caution w/ other benzodiazepines, may need a reduced dose concurrent EtOH and caffeine use can t CNS effects OD May cause alt ed reflexes, drowsiness, CNS depression, slurred speech, and Szs flumazenU can be used as an antidote... 

Ginseng is generally considered safe for nonpregnant healthy adults however, at sufficient doses, ginseng may elevate blood pressure and cause insomnia, palpitations, nervousness, and tremor in susceptible individuals. These effects are increased if caffeine or other stimulants are taken concurrently. Both Panax and Siberian... 

CNS The caffeine and theophylline are pharmacologically CNS stimulants and produce alertness and cortical arousal, but in higher doses causes restlessness, nervousness and insomnia. 

In low and moderate doses, the methylxanthines—especially caffeine—cause mild cortical arousal with increased alertness and deferral of fatigue. The caffeine contained in beverages—eg, 100 mg in a cup of coffee—is sufficient to cause nervousness and insomnia in sensitive individuals and slight bronchodilation in patients with asthma. The larger doses necessary for more effective bronchodilation commonly cause nervousness and tremor in some patients. Very high doses, from accidental or suicidal overdose, cause medullary stimulation and convulsions and may lead to death. 

CNS, smooth muscle T diuresis X- pit aggregation Available forms Daily t doses w/ max 3 g PO daily Contra Avoid in PRG lactation, CAD, hyperthyroidism, anxiety disorders d/t high, caffeine content Notes/SE Insomnia, tach, anxiety, N/V, HA, HTN, Sz Interactions T Effects OF anticoagulants, anti-pits, BBs, bron-choclilators T risk of hypertensive crisis W/ MAOIs T effects W/ cimetidine, ciprofloxacin, ephedrine, hormonal contraceptives, dieophylline, cola, coffee X-effects OF adenosine, antihypertensives, benzodiazepines, Fe, X- effects W/ smoking EMS Tinctures contain EtOH may exacerbate GI disorders HTN T effects of anticoagulants and BBs... 

The symptoms of jitters, insomnia, tremors, and agitation are common in those consuming caffeine and in those with depression or the other illnesses for which these drugs are prescribed. Combining caffeine with antidepressants may exaggerate the symptoms and make it difficult for the physician to arrive at an accurate diagnosis or evaluate the drug s effectiveness. 

Frankly toxic effects, such as persistent insomnia and anxiety, only become evident when people drink more than eight or nine cups of coffee or tea a day. Convulsions and delirium can follow enormous doses, and a near-fatal dose can induce a state similar to that of a diabetic lacking insulin. Blood sugar surges, and ketones appear in the urine. The lowest recorded fatal dose of caffeine was 3200 mg, which was given by accident directly into the bloodstream. It takes the equivalent of 40 cups of coffee consumed by mouth in a short interval for caffeine to kill a person. 

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