Initiators, carcinogen risk assessment

By assuming TCDD Is an Initiator when the data attest to the contrary, EPA and CDC are not Incorporating all the available data Into their assessments. In EPA s "Proposed Guidelines for Carcinogen Risk Assessment" ( ), they stipulate that models used In risk assessment should reflect data on mechanism of carcinogenesis ... 

The first section of this chapter provides a discussion of hazard assessment, classification of potentially dangerous substances, and the process of risk assessment. A summary of the mandatory and voluntary initiatives for regulating chemicals and biocides in the United States and Europe is also included together with information on the regulatory aspects of hazard communication. The second section deals with the scientific aspects of hazard identification and risk assessment of carcinogenic chemicals within the regulatory context. 

Burns, R, Albert, R., Altshuler, B., and Morris, E. (1983). Approach to risk assessment for genotoxic carcinogens based on data from the mouse skin initiation-promotion model. Environ Health Perspect 50, 309-320. 

Despite the challenges that nonlinear extrapolation for carcinogens offers in terms of regulatory implementation, it is important that the best available science guide risk assessment practices. Default assumptions designed to be health-protective, such as low-dose linear assumption, are useful when no other alternatives are available, but public health initiatives will be best served when grounded in biologically based approaches. 

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