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Inhibitors chloroquine

Chibale K, Visser M, van Schalkwyk D, Smith PJ, Saravanamuthu A, Fairlamb AH (2003) Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents. Tetrahedron 59 2289-2296... [Pg.184]

Chagas disease is caused by a kinetoplastid trypanosoma parasite and affects millions of people in Latin America. The disease is currently incurable. Chemotherapy is based mainly on nitrofuran and nitroimidazole compounds and sterol biosynthesis inhibitors such as ketoconazole (337). Toxicity and high doses are the major problems for these organic drugs. Urbina et al. (338, 339) have found that com-plexation of antiparasitic organic agents such as chloroquine (78)... [Pg.241]

Increased bilirubin levels are caused due to the intake of large doses of such drugs as chloroquine, vitamin K, sulpha-drugs, tetracyclines, paracetamol, nicotinic acid and monoamine oxidase inhibitors (e.g., iproniazid RP 1.0 nialamide RP 1.8 isocarboxazid RP 3.1 phenelzine RP 18 pheniprazine RP31 and tranylcypromine RP 45), where RP designates the Relative Potency based on the tiyptamine potentiation test. The elevated levels are due to hepatic injury, and... [Pg.57]

VI.a.2.2. Biguanides. Proguanil is a dihydrofolate reductase inhibitor. It is a slow acting blood schizonticide and not effective on its own. It has also a marked effect on the primary tissue stages of Plasmodium falciparum. It is used in combination with chloroquine for the prophylaxis of chloroquine-resistant Plasmodium falciparum. [Pg.426]

VI.a.2.4. Diaminopyrimidines. Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum... [Pg.426]

The sulfones and sulfonamides synergize with the inhibitors of dihydrofolate reductase, and the combinations have been effective in controlling malaria, toxoplasmosis, and coccidiosis. Fansidar, a combination of sulfadoxine and pyrimethamine, has been successful in controlling some strains of chloroquine-resistant Plasmodium falciparum malaria (see Chapter 53 Antiprotozoal Drugs). However, reports of Fansidar resistance have increased in recent years. New inhibitors effective against the sulfonamide-resistant 7,8-dihydropteroate synthase are needed. [Pg.1193]

Agents causing phospholipidosis amiodarone, chloroquine, DMP-777 (a neutrophil elastase inhibitor). [Pg.1627]

Cloquinate [ban, inn] is a chloroquine derivative with AMOEBiciDAL properties. Clinically, it can be used as an ANTlMALARiAL prophyaxis and treatment, cloracetadol [inn] is one of the para-aminophenol series, a weak cyclooxygenase inhibitor with NSAID ANALGESIC, ANTIINFLAMMATORY and ANTIPYRETIC activity. [Pg.80]

The most specific metabolizing enzyme is imidazole N-methyl-transferase ( histamine acetylase ), which can be inhibited in vivo by amodiaquine, chloroquine and metoprine. Histamine is also metabolized by hlstaminase , and this enzyme can be inhibited by aminoguanidine, metronidazole and pentamidine (see diamine oxidase inhibitors). Metabolites in the urine can be measured to give some index of histamine turnover. [Pg.143]

Clinically important, potentially hazardous interactions with acetazolamide, aminoglycosides, anticholinesterases, bambuterol, calcium channel blockers, chloroquine, chlorpromazine, clindamycin, d-pencillamine, ecothiophate iodine, enflurane, furosemide, halothane, hexomethonium, isoflurane, ketamine, lidocaine, lincomycin, lithium salts, magnesium salts, mannitol, MAO inhibitors, organophosphates, pancuronium, phenytoin, polymyxins, procainamide, quinidine, sevoflurane, spectinomycin, tetracyclines... [Pg.389]


See other pages where Inhibitors chloroquine is mentioned: [Pg.101]    [Pg.169]    [Pg.101]    [Pg.169]    [Pg.274]    [Pg.200]    [Pg.356]    [Pg.449]    [Pg.12]    [Pg.101]    [Pg.302]    [Pg.422]    [Pg.228]    [Pg.295]    [Pg.1313]    [Pg.1322]    [Pg.1313]    [Pg.1322]    [Pg.148]    [Pg.153]    [Pg.164]    [Pg.295]    [Pg.343]    [Pg.347]    [Pg.348]    [Pg.192]    [Pg.320]    [Pg.340]    [Pg.220]    [Pg.134]    [Pg.138]    [Pg.145]    [Pg.525]    [Pg.101]    [Pg.153]    [Pg.164]    [Pg.693]   
See also in sourсe #XX -- [ Pg.362 ]




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