Inflammatory bowel disease ulcerative colitis

Inflammatory bowel disease (ulcerative colitis and Crohn s disease) Hereditary/Genetic... 

Gastrointestinal system (inflammatory bowel disease [ulcerative colitis, Crohn s disease], peptic ulcer, pancreatitis, cholecystitis, hepatitis, choledocholithiasis)... 

Site-specific delivery and release of drugs will not only be useful to achieve systemic therapeutic effects (after absorption), but also topical applications, for instance for the treatment of inflammatory bowel disease, ulcerative colitis, and colon cancer, to name the most prevalent. 

Inflammatory bowel disease (ulcerative colitis and Crohn s disease) is a general term for a group of chronic inflammatory disorders of unknown cause involving the gastrointestinal tract. Despite many attempts to confirm an infectious agent as the cause of disease, no bacterial. 

Several quite different mechanisms can lead to diarrhea. In carbohydrate malabsorption, the presence of unabsorbed solutes in the bowel causes an osmotic diarrhea as water enters the bowel from the tissue. By contrast, the diarrhea of most laxative abuse and in VIPomas is due to active secretion of water and electrolytes into the bowel, which is described as secretory diarrhea. Inflammatory bowel diseases (ulcerative colitis and Crohn s disease) cause diarrhea as a consequence of the inflammatory process with loss of fluid into the bowel. 

Glickman RM. Inflammatory bowel disease (ulcerative colitis and Crohn s disease). In Harrison s Principles of Internal Medicine (13 h edition, volume 2). Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (editors). McGraw-Hill, In, New York, p. 1403-1417. 

Inflammatory bowel disease Ulcerative colitis Crohn s disease Localization of sepsis Localization of abscesses... 

Chronic inflammatory bowel conditions (ulcerative colitis, Crohn s disease) treated by mesalazine, beclometasone and budesonide given as a suppository or enema for a local action, but only if the disease is limited to the rectum (suppository) and the distal part of the colon (enema). 

Colon inflammation 1. AEA levels are elevated in the colon of DNBS-treated mice and in the colon submucosa of TNBS-treated rats, two animal models of inflammatory bowel diseases, and in the biopsies of patients with ulcerative colitis, to control inflammation 1. Inhibitors of degradation (both FAAH and cellular re-uptake)... 

The glucocorticoids are administered with caution to patients with renal or hepatic disease hypothyroidism, ulcerative colitis, diverticulitis, peptic ulcer disease, inflammatory bowel disease hypertension, osteoporosis, convulsive disorders, or diabetes. The glucocorticoids... 

Inflammatory bowel disease (IBD) encompasses both Crohn s disease (CD) and ulcerative colitis (UC). Both disorders are associated with inflammation of various regions within the gastrointestinal (GI) tract. Differences exist between UC and CD with regard to the regions of the GI tract that may be affected as well as in the distribution and depth of inflammation. Some... 

Inflammatory bowel disease is most common in westernized countries such as the United States. Ulcerative colitis affects up to 500,000 people and Crohn s disease affects up to 480,000 people in the United States.2-4 The age of initial presentation of IBD is bimodal, with patients typically diagnosed between the age ranges of 20 to 40 years or 60 to 80 years.5 The peak incidence of CD occurs in the second and third decades of life, with a smaller peak in the fifth decade.2,5 Peak incidence of UC occurs between the ages of 15 and 25 years.6... 

Inflammatory (or exudative) diarrhea results from changes to the intestinal mucosa that damage absorption processes and lead to an increase in proteins and other products in the intestinal lumen with fluid retention. The presence of blood or fecal leukocytes in the stool is indicative of an inflammatory process. The diarrhea of inflammatory bowel disease (e.g., ulcerative colitis) is inflammatory in nature. 

There are two forms of idiopathic inflammatory bowel disease (IBD) ulcerative colitis, a mucosal inflammatory condition confined to the rectum and colon, and Crohn s disease, a transmural inflammation of GI mucosa that may occur in any part of the GI tract. The etiologies of both conditions are unknown, but they may have a common pathogenetic mechanism. 

Other studies describe similar beneficial effects for PUFA-enriched diets to treat Crohn s disease, other inflammatory bowel diseases such as ulcerative colitis, as well as psoriasis, asthma, systemic lupus erythematosus, and multiple sclerosis [57], Thus, immunomodulation by PUFAs appears to be a promising intervention for the treatment of many autoimmune and inflammatory diseases. 

Sulfasalazine Antimicrobial anti-inflammatory ulcerative colitis/inflammatory bowel diseases Suppresses NK cells impaired lymphocyte function... 

Inflammatory Bowel Disease (IBD) comprises several diseases, including ulcerative colitis and Crohn s disease. Ulcerative cohtis is a disease of the colon, originating in the rectum and extending proximally to a variable extent. It frequently affects the entire colon but never... 

Glucocorticoid therapy is indicated in selected patients with inflammatory bowel disease, chronic ulcerative colitis as well as Crohn s disease. Agents include prednisolone, hydrocortisone and budes-onide, the latter having a predominantly local effect... 

Indications for glucocorticosteroids include adrenal insufficiency and inflammatory, non-infectious processes of all sorts such as various types of arthritis, auto-immune diseases, asthma, inflammatory bowel diseases, especially Crohn s disease but also ulcerative colitis and further many skin diseases and some diseases of the eye. Their antimitotic activity is used in various anti-cancer chemotherapeutic regimens. They still have an important place... 

The autoimmune rheumatic diseases consists of Rheumatoid Arthritis (RA), Spondylarthritis (SpA), Systemic Lupus Erythematosus (SLE), Polymyositis, Dermatomyositis, Polymyalgia Rheumatica, Acute Temporal Arteritis, Giant Cell Arteritis, Behcet s Disease, Sjorgren s Syndrome, Felty s Syndrome and Mixed Connective Tissue Disease (MCTD). Spondylarthritis (SpA) can be subdivided in Reactive Arthritis (ReA), Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Arthritis associated with the inflammatory bowel diseases are Crohn s disease and Ulcerative Colitis (IBD), Undifferentiated SpA (UspA) and Sacro-ilitis, Juvenile SpA and Acute Anterior Uveitis (AAU). 

Arthritis of IBD comprises rheumatic syndromes associated with IBD. Inflammatory bowel disease consists of Crohn s disease and Ulcerative Colitis. Gut inflammation is common in patients with SpA. Around 25% of patients with chronic SpA have early features of Crohn s disease. 

Kader, H.A., et al. (2005) Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-betal, and IL-12p40 levels in Crohn s disease and ulcerative colitis patients in remission versus active disease. Am J Gastroenterol. 100, 414-23. 

Sulfasalazine (salicylazosulfapyridine) is widely used in ulcerative colitis, enteritis, and other inflammatory bowel disease (see Chapter 62). 

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