Inferior colliculus

Figure 6.2 The location and distribution of the histamine-containing neurons in the brain. These neurons are localized in the tuberomammiUaiy nucleus within the posterior hypothalamus and send projections throughout the brain. Abbreviations Hi, hippocampus Hy, hypothalamus IC, inferior colliculus OB, olfactory bulb SC, superior colliculus SI, substantia innominata St, striatum TH, thalamus TMN, tuberomammillary nucleus. Adapted from Watanabe Yanai (2001).

A recent study showed significant increases of expression of eNOS in the brains of rats treated with pyrithia-mine [20]. Increased eNOS expression was apparent prior to the onset of neurological symptoms and was restricted to vulnerable medial thalamus and inferior colliculus. Expression of inducible (iNOS) and neuronal (nNOS) isoforms were minimally altered in brain in thiamine deficiency and it has also been shown that targeted disruption of the eNOS (but not the iNOS or nNOS) gene results in reduced extent of neuropathological damage in thalamus of thiamine deficient animals [21] (Fig. 34-5). 

Lamprea MR, Cardenas FP, Vianna DM, Castilho VM, Cruz-Morales SE, Brandao ML (2002) The distribution of fos immimoreactivity in rat brain following freezing and escape responses elicited by electrical stimulation of the inferior colliculus. Brain Res 950 186-194 Lechner HA, Squire LR, Byrne JH (1999) 100 years of consolidation—remembering Muller and Pilzecker. Learn Mem 6 77-87... 

Cerebral cortex (layer I-VI, selected interneurons and principal cells) hippocampus (selected interneurons and principal cells) pallidum striatum (interneurons) thalamic relay nuclei olfactory bulb (mitral cells and interneurons) cerebellum (Purkinje cells and granule cells) deep cerebellar nuclei amygdala basal forebrain substantia nigra pars reticulata inferior colliculus brainstem... 

This interpretation finds support in systematic studies of responses from brainstem nuclei following successive coagulative lesion production in the auditory loci (1 7). The effect of brainstem lesions on electrical potentials recorded from the superior olivary (SO) nucleus in response to microwave pulse stimulation is shown in Figure 3. Lesions in proximal nuclei (inferior colliculus, IC and lateral lemniscus, LL) had negligible influence on the response recorded from superior olivary nucleus. The response, however, disappeared after a lesion was made in its nucleus, thus, confirming the peripheral nature of the primary site of transduction. 

Haemorrhagic lesions are characteristic of experimental thiamine deficiency and WE in humans indicative of a breakdown of the blood-brain barrier (BBB). A study using immunoglobulin G (IgG) as an indicator of BBB integrity in thiamine-deficient rats revealed increased IgG immunoreactivity in the inferior colliculus and inferior olive prior to the onset of cell death in these regions (Calingasan et al.,... 

Neuroscience communities concerned with different systems have developed identical abbreviations for completely different structures for example SO stands for both supraoptic nucleus and superior olive, SC for suprachiasmatic nucleus and superior colliculus, and IC for inferior colliculus and internal capsule. In dealing with the entire nervous system (as increasingly more researchers do) these parochial abbreviation schemes become impossible to implement. An additional complication arises when homologous structures are nonetheless named or abbreviated differently in different species. We have made an effort to establish homologies and are using the same abbreviations for homologous... 

Refer to Webster (1995) for a general description of the auditory system. We used Faye-Lund and Osen (1985) as well as Malmierca etal. (1995) for the identification of areas of the inferior colliculus. The medial geniculate was delineated according to the work of LeDoux et al. (1985). For additional details on the basis of delineation of the components of the auditory system refer to Paxinos and Watson (1986). 

CIC central nucleus of the inferior colliculus 54-58, 81-84,106-115 cic commissure of the inferior colliculus 53-56, 79-81,111-116 Cir circular nucleus 24,94... 

Fuzessery ZM, HaU JC. 1996. Role of GABA in shaping frequency tuning and creating FM sweep selectivity in the inferior colliculus. J Neurophysiol 76 1059-1073. 

Fig. 170. Laterality and somatotopical organization of the projection zones of the ventral funiculus spino-olivocerebellar climbing fiber path (VF-SOCP) in the cerebellum of the cat. A. Rostral aspect. B. Caudal aspect of the cerebellum. The position of the caudal border of the inferior colliculus (INF.COLL.) is indicated. Oscarsson and Sjolund (1977b).

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