Industrial safety tools, traditional

Again, traditional occupational and industrial safety tools like job safety analysis (JSA) should also be used. 

Food authentication is one of the major areas involved in food quality and safety. Several regulations have been implemented to assure correct information and to avoid species substitutions (26). Food species identification has traditionally relied on morphological/anatomical analysis. However, this is a difficult task in the case of closely related species and especially for those products that have been subjected to processing practices. Therefore, there is a strong need for fast and reliable molecular identification methods that provide authorities and food industries the tools needed to comply with labeling and traceability requirements, thus ensuring product quality and protection of the consumer. 

Some of the hazard analysis (evaluation) techniques already used by the chemical industry include traditional system safety tools such as preliminary hazard analysis, failure modes and effects analysis, and fault tree analysis. 

The qualification of novel DILI biomarkers will require application to biospecimens obtained from many different patient populations treated with many different drugs, both those that cause clinically important DILI and those that cause elevations in traditional liver chemistries but do not cause clinically important liver injury. It is important that pharmaceutical companies start now to archive samples and link these specimens to the relevant liver safety data. Ideally, liver safety data management tools should be standardized across the industry to facilitate the precompetitive collaborations on biomarker validation and qualification, such as eDISH (Watkins et al., 2011). Formal biomarker validation and qualification will warrant significant time to obtain regulatory-endorsed exploratory status via Letters of Support. 

It should be remembered that resilience, or the art of adapting to exceptional conditions, is a native feature of human systems that rely on their own autonomy to survive it automatically disappears as a result of using the traditional tools that enhance safety in industry and service sectors. In many cases it would be preferable to have less of this in less safe systems (because it is associated with frequent improvisation and habitual non-compliance) and also to reintroduce it in ultra-safe systems (because it would permit adaptation to exceptional situations, an ability which by this stage has largely been lost). 

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