Industrial Microorganisms Saccharomyces cerevisiae and other Yeasts

Industrial Microorganisms Saccharomyces cerevisiae and other Yeasts 

Diethard Mattanovich, Brigitte Gasser, Michael Egermeier, Hans Marx, and Michael Sauer 

Yeast was the first microbial host used by mankind for biotransformation of raw materials, and it marked the early developments of industrial biotechnology. Initially, Saccharomyces cerevisiae and closely related species were used because of their high fermentative capacity and based on the vast experience from alcoholic beverage production. While a high fermentation rate is favorable for the production of bioethanol and other primary metabolites, it implicates disadvantages for growth-coupled production. Consequently, a number of other yeasts have been developed for the production of biofuels, biochemicals, lipids, or recombinant proteins. 

Modern fermentation technology emerged from beer and wine production, and it is based on batchwise processing of highly concentrated media where most of the sugar taken up by the cells is efficiently channeled into the metabolic 

The peculiar metabolic features of S. cerevisiae explain why this yeast is especially suitable for overproduction of metabolites, while other yeasts with predominantly respiratory phenotype have advantages for the production of biomass-related products such as recombinant proteins. Natural hmitation of sugar uptake hmits overflow metabolism in these yeasts, channeling substrate into growth-related products. Table 18.1 provides an overview of yeasts used in biotechnology. 

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Industrial Microorganisms Saccharomyces cerevisiae and other Yeasts Lignocellulose Glycerol... 

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