Indinavir Nelfinavir

Estrogens, furosemide, hydrochlorothiazide, interferon alfa-2b, isotretinoin, propofol, and protease inhibitors (e.g., indinavir, nelfinavir, ritonavir, and saquinavir)... 

Rifampin Daily for 4 months For persons who are contacts of patients with isoniazid-resistant rifampin susceptible TB. In HIV-infected patients, protease inhibitors or NNRTIs generally should not be administered concurrently with rifampin rifabutin can be used as an alternative for patients treated with indinavir, nelfinavir, amprenivir, ritonavir, orefavirenz, and possibly with nevirapine or soft-gel saquinavir5 B (II) B (III)... 

HIV-1 protease inhibitors Ritonavir Aquinavir Saquinavir Indinavir Nelfinavir... 

St. John s wort, rifamycins, and ritonavir. Drugs that may be affected by efavirenz include phenytoin, phenobarbital, carbamazepine, itraconazole, ketoconazole, methadone, ritonavir, amprenavir, benzodiazepines, clarithromycin, ethinyl estradiol, indinavir, nelfinavir, saquinavir, and warfarin. 

Chemotherapy Cyclophosphamide, erlotlnlb, ifos-famide, paclitaxel, tamoxifen, vinblastine, vincristine HIV protease inhibitors Amprenavir, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir HMG-CoA reductase inhibitors Atorvastatin, lovastatin, simvastatin... 

Amprenavir Nelfinavir Indinavir Indinavir Nelfinavir Ritonavir ... 

Anti-HIV agents Indinavir Nelfinavir Ritonavir Saquinavir Others Losartan Sildenafil Nefazodone ... 

PgP MDRl (3435 C T) 24 (W) Increase plasma drug concentrations in 24% (W) population Digoxin, Saquinavir, Ritonavir, Indinavir, Nelfinavir... 

Lopinavir/ritonavir Indinavir, nelfinavir, ritonavir, saquinavir... 

At the present time, there are at least 14 compounds that have been formally approved for the treatment of human immunodeficiency virus (HIV) infections. There are six nucleoside reverse transcriptase inhibitors (NRTIs) that, after their intracellular conversion to the 5 -triphosphate form, are able to interfere as competitive inhibitors of the normal substrates (dNTPs). These are zidovudine (AZT), didanosine (ddl), zalcitabine (ddC), stavudine (d4T), lamivudine (3TC), and abacavir (ABC). There are three nonnucleoside reverse transcriptase inhibitors (NNRTIs) — nevirapine, delavirdine, and efavirenz — that, as such, directly interact with the reverse transcriptase at a nonsubstrate binding, allosteric site. There are five HIV protease inhibitors (Pis saquinavir, ritonavir, indinavir, nelfinavir, and amprenavir) that block the cleavage of precursor to mature HIV proteins, thus impairing the infectivity of the virus particles produced in the presence of these inhibitors. 

Acyclovir Erythromycin Ivermectin Itraconazole Rifampin Actinomycin D Daunorubicin Doxorubicin Docetaxel Epirubicin Etoposide Imatinib Irinotecan Paclitaxel Vinblastine Vincristine Amprenavir Indinavir Nelfinavir Ritonavir Saquinavir Cyclosporine A Tacrolimus Digoxin Quinidine Verapamil Diltiazem Aldosterone Cortisol Corticosterone Dexamethasone Hydrocortisone Cyclosporine Metkephamid Enkephalin... 

Saquinavir could be considered an abnormal peptide. Its bioavailability is low. Ritonavir, indinavir, nelfinavir, and amprena-... 

PHENYTOIN PROTEASE INHIBITORS Possibly 1 efficacy of phenytoin, with a risk of fits when coadministered with indinavir, nelfinavir and ritonavir (with or without lopinavir) Uncertain 1 plasma levels of phenytoin Use with caution. Monitor phenytoin levels weekly. Adjust doses at 7-10-day intervals. Maximum suggested dose adjustment each time is 25 mg... 

ALMOTRIPTAN, ELETRIPTAN PROTEASE INHIBITORS -INDINAVIR, NELFINAVIR, RITONAVIR Possibly t adverse effects when almotriptan or eletriptan is coadministered with indinavir, ritonavir (with or without lopinavir), or nelfinavir Inhibition of CYP3A4- and possibly CYP2D6-mediated metabolism of eletriptan, and CYP3A4-mediated metabolism of almotriptan Avoid co-administration... 

MODAFINIL 1. ANTIBIOTICS-clarithromycin, telithromycin 2. ANTIFUNGALS-itraconazole, ketoconazole 3. ANTIVIRALS-indinavir, nelfinavir, ritonavir, saquinavir t plasma concentrations of modafinil, with risk of adverse effects Due to inhibition of CYP3A4, which has a partial role in the metabolism of modafinil Be aware. Warn patients to report dose-related adverse effects, e.g. headache, anxiety... 

INDINAVIR NELFINAVIR Possibly t efficacy and t adverse effects of both Inhibition of CYP3A4-mediated metabolism Uncertain if interaction is clinically significant however, monitor more closely for adverse effects... 

CANNABIS ANTIVIRALS-PROTEASE INHIBITORS-indinavir, nelfinavir, nevirapine, ritonavir, saquinavir Cannabis may cause l plasma concentrations of protease inhibitors, particularly indinavir and nelfinavir Cannabis may cause inhibition or induction of CYP3A4 isoenzymes, which metabolize these protease inhibitors Be aware. Regular monitoring of viral indicators is necessary... 

In an open, randomized study of amprenavir combined with indinavir, nelfinavir, and saquinavir (10) the amprenavir AUC increased by 35% when it was combined with indinavir, and indinavir concentrations also fell, suggesting that this protease inhibitor combination should be avoided. There was no significant interaction of amprenavir with nelfinavir. 

The use of rifampicin with the protease inhibitors indinavir, nelfinavir, and amprenavir is contraindicated. However, these agents can be used with rifabutin after appropriate dosage reduction. Failure to reduce the dosage of rifabutin can result in toxic manifestations, such arthralgia and uveitis. 

Clinically important, potentially hazardous interactions with amprenavir, chlorpheniramine, clarithromycin, efavirenz, esomeprazole, imatinib, indinavir, nelfinavir, oxycodone, piracetam... 

Successful treatment of human immunodeficiency virus (HIV-1) infection has been achieved through successful implementation of highly active antiretroviral therapy, frequently referred to as HAART. This involves simultaneous administration of both nucleoside and nonnucleoside reverse transcriptase inhibitors and one or more protease inliibitors. The common nucleoside reverse transcriptase inhibitors are the thymidine analogs didanosine (ddl), lamivudine (3TC), and zalcitabine (ddC) and the non-thymidine analogs abacavir (Ziazen), stavudine (d4T), and zidovudine (AZT). The nonnucleoside reverse transcriptase inhibitors include delavirdine, efavirenz, and nevirapine. The protease inhibitors include indinavir, nelfinavir, ritonavir, and saquinavir. Response to therapy is monitored by quantification of HIV-RNA copies (viral load) and CD-4+ T-lymphocyte count. Successful therapy is indicated when viral load is reduced to <50 copies/mL and CD-4+ count >500 per mL. 

HIV protease inhibitors Indinavir Nelfinavir Ritonavir Saquinavir Amiodarone not Azithromycin Cimetidme Clarithromycin . Diltiazem Erythromycin Fluoxetine Fluvoxamine Grapefruit Juice Itraconazole Ketoconazole Mibefradil Nefezodone Troleandomydn Verapamil... 

HIV-protease inhibitors Ritonavir, saquinavir, indinavir, nelfinavir p-GP Mrp2... 

The other type of anti-HIV drugs are the HIV-protease inhibitors such as saquinavir, indinavir, nelfinavir, ritonavir and amprenavir. 

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