Cannabis Nelfinavir

CANNABIS ANTIVIRALS-PROTEASE INHIBITORS-indinavir, nelfinavir, nevirapine, ritonavir, saquinavir Cannabis may cause l plasma concentrations of protease inhibitors, particularly indinavir and nelfinavir Cannabis may cause inhibition or induction of CYP3A4 isoenzymes, which metabolize these protease inhibitors Be aware. Regular monitoring of viral indicators is necessary... 

The short-term use of cannabis cigarettes or dronabinol did not appear to adversely affect indinavir or nelfinavir levels or viral loads in HIV-positive patients. 

In another 11 patients on a stable regimen containing nelfinavir 750 mg three times daily, there was a non-significant 10% decrease in AUC, 17% decrease in maximum level, and 12% decrease in minimum nelfinavir level after 14 days of cannabis cigarettes. Similarly, dronabinol 2.5 mg three times daily for 14 days had no significant effect on nelfinavir pharmacokinetics. ... 

Short-term use of cannabis cigarettes or dronabinol does not appear to have any important effect on levels of indinavir or nelfinavir, nor on markers of HIV infection. 

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See also in sourсe #XX -- [ ]

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