Indinavir Amprenavir

Amprenavir, indinavir, nelfinavir, ritonavir, saquinavir Allopurinol Argatroban Aspirin Amoxicilhn Captopril, enalapril... 

Azalides azithromycin Azoles fluconazole, itraconazole, ketoconazole, and voriconazole Macrolides erythromycin, clarithromycin Protease inhibitors amprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, and saquinavir Quinolones ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin. 

Efavirenz Nelfinavir Ritonavir Amprenavir Indinavir Ritonavir Saquinavir... 

Ritonavir Amprenavir Indinavir Lopinavir Nelfinavir Saquinavir ... 

Protease inhibitors amprenavir indinavir sulfate nelfinavir ritonavir... 

Nevirapine is a moderate inducer of CYP3A metabolism, resulting in decreased levels of amprenavir, indinavir, lopinavir, saquinavir, efavirenz, and methadone (Table 49-4). Drugs that induce the CYP3A system, such as tipranavir, rifampin, rifabutin, and St. John s wort, can decrease levels of nevirapine, whereas those that inhibit CYP3A activity, such as fluconazole, ketoconazole, and clarithromycin, can increase nevirapine levels. 

Acyclovir Erythromycin Ivermectin Itraconazole Rifampin Actinomycin D Daunorubicin Doxorubicin Docetaxel Epirubicin Etoposide Imatinib Irinotecan Paclitaxel Vinblastine Vincristine Amprenavir Indinavir Nelfinavir Ritonavir Saquinavir Cyclosporine A Tacrolimus Digoxin Quinidine Verapamil Diltiazem Aldosterone Cortisol Corticosterone Dexamethasone Hydrocortisone Cyclosporine Metkephamid Enkephalin... 

CILOSTAZOL ANTIVIRALS-PROTEASE INHIBITORS Amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir t cilostazol levels These protease inhibitors inhibit CYP3A4-mediated metabolism of cilostazol Avoid co-administration... 

Protease inhibitors are metabolized by CYP3A4, and ritonavir is also metabolized by CYP2D6. Ritonavir inhibits CYP3A4, CYP2D6, CYP2C9 and CYP2C19. Amprenavir, indinavir and nelfinavir are moderately potent CYP3A4 inhibitors. 

RIFABUTIN PROTEASE INHIBITORS t efficacy and t adverse effects of rifabutin Inhibition of CYP3A4-mediated metabolism. Nelfinavir also competitively inhibits 2C19 1 rifabutin dose by at least 50% when given with amprenavir, indinavir or nelfinavir, and by 75% with atazanavir, ritonavir (with or without lopinavir) or tipranavir... 

ITRACONAZOLE, KETOCONAZOLE PROTEASE INHIBITORS Possibly t levels of ketoconazole by amprenavir, indinavir and ritonavir (with or without lopinavir). Conversely, indinavir, ritonavir and saquinavir levels t by itraconazole and ketoconazole Inhibition of, or competition for, CYP3A4-mediated metabolism Use itraconazole with caution and monitor for adverse effects. No dose adjustment is recommended for doses <400 mg/day of ketoconazole... 

Amprenavir, indinavir, lopinavir, nelflnavir, ritonavir and saquinavir... 

Preferred Pl-based regimens are lopinavir/ritonavir plus lamivudine or emtricitabine plus another NRTI, usually zidovudine, stavudine or abacavir. Alternative combinations include other Pis with or without ritonavir, and two NRTIs. The combination of a protease inhibitor with ritonavir provides inhibition of cytochrome p450 enzymes and permits less frequent dosing of amprenavir, indinavir, lopinavir and saquinavir. Use of ritonavir in this setting is also known as boosting. ... 

Drugs in this dass, which inhibit HIV protease leading to impaired maturation of noninfectious HIV virions, indude amprenavir, indinavir, lopinavir, nelfi-navir, ritonavir, and saquinavir. There are no published reports of ARF or other direct renal toxidty due to amprenavir, nelfinavir, and lopinavir. 

In a study in 11 HTV-positi ve patients taking efavirenz 600 mg once daily with various NRHs, there was no change in the pharmacokinetics of efavirenz after they took valproic acid 250 mg twice daily for 7 days. Valproic acid levels achieved in these patients were not significantly different from those in 11 HIV-positive control patients mainly taking NRTI antiretrovirals, even when the 3 control patients taking a protease inhibitor or NNRTI (amprenavir, indinavir, or nelfrnavir plus nevirapine) were excluded. ... 

Itraconazole increasiesi the levels of amprenavir, indinavir, lopina-vir/ritonavir, and siaquinavir, and may theoretically increase the levels of other protease inhibitors. 

Nelfinavir approximately doubles the sierum levels of azithromycin, but the ciinical significance of this is uncertain. Single doses of azithromycin have no effect on the levels of indinavir and nelfinavir. Ritonavir and atazanavir increase clarithromycin leveis. Amprenavir, indinavir and saquinavir do not have a clinically significant effect on clarithromycin pharmacokinetics. Clarithromycin has no important effect on the pharmacokinetics of amprenavir, atazanavir, darunavir, indinavir or ritonavir, but it increases tipranavir levels. Although both clarithromycin and erythromycin markedly raise saquinavir levels, this is not considered clinically important for short courses of these antibacteriais. 

DaiUy, E. Thomas, L. Kergueris, M.F. JolUet, P. Bourin, M. High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelflnavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid extraction, J.Chromatogr.B, 2001, 758, 129-135. 

Faux, J. Venisse, N. Le Motil, G. Dupuis, A. Bouquet, S. Simultaneous determination of six HIV protease inhibitors, one metabolite, and two non-nucleoside reverse transcriptase inhibitors in human plasma by isocratic reversed-phase liquid chromatography after solid-phase extraction, Chromatographia 2003, 58, 421-426. [amprenavir indinavir lopinavir nelflnavir ritonavir saquinavir efavirenz nevirapine prazepsun]... 

Poirier, J.-M. Radembino, N. Robidou, P. JaUlon, P. Simultaneous determination of the five HIV-protease inhibitors Amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir in human plasma by sohd-phase extraction and column liquid chromatography, Ther.Drug Monit., 2000,22, 465-473. 

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