INDEX narcotics

Opioids/narcotics (codeine, fentanyl, hydrocodone, hydromorphone, meperidine [Demerol], morphine, oxycodone [OxyContin], propoxyphene [Darvon]) (see also individual agents in index) Street Names ... 

Finkle et al. (46) have established a GC/MS reference data system for the identification of drugs of abuse. The data include phenethylamine derivatives, opiate and synthetic narcotics, barbiturates, and urinary metabolites. These data have been established for use with the gas chromatographic retention time index previously developed. 

Properties Clear, colorless liquid pleasant odor. Bp 91.2C, fp -112C, d 1.2425 (25/25C), refr index 1.4320-1.4344 (25C), flash p 70F (21.1C) (OC). Soluble in alcohol and ether insoluble in water. Hazard Narcotic in high concentration. Flammable, dangerous fire risk. 

Properties Water-white, mobile liquid distinctive ethereal odor somewhat like peppermint. Bp 131C d 0.943 refr index 1.437 flash p 87F (30.5C) (CC) insoluble in water soluble in alcohol and ether. Hazard Flammable, moderate fire risk. Narcotic in high concentration. 

It is a mobile, narcotic, flammable liquid whose over-exposure irritates eyes and upper respiratory system (Merck Index). It has a sweet-ethereal, fruity taste in water (Arctander, 1967). An odor threshold of 17 ppm in water was given by Mulders (1973b). 

USE Determining refractive index of minerals filling for thermometers instead of mercury, usually with a blue or red dye. Caution May be irritating to respiratory tract and, in high conens, narcotic. 

Properties Colorless liq., faint odor misc. with alcohol pract. insol. in water m.w. 208.33 dens. 0.933 (20/4 C) vapor pressure 12 mm (60 C) m.p. -77 C b.p. 165-166 C flash pt, (OC) 52 C ref. index 1.383 (20 C) sp. heat 0.55 cal/g/C dielec, const. 4.1 Toxicology ACGIH TLV/TWA10 ppm LD50 (oral, rat) 6270 mg/kg, (skin, rabbit) 5878 mg/kg LDLo (IV, rabbit) 200 mg/kg LCLo (inh., rat, 4 h) 1000 ppm poison by IV route mod. toxic by other routes strong irritant to eyes, nose, throat narcotic in high cones. TSCA listed Precaution Flamm. can react vigorously with oxidizers Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and fumes... 

C flash pt. (CC) 29.4 C ref. index 1.5 Toxicology ACGIH TLV/TWA 10 ppm LD50 (oral, rat) 2910 mg/kg toxic poison by ing., mod. toxic by IP route strong narcotic inh. causes CNS depression, headaches, nausea, dizziness, drowsiness, confusion experimental... 

Properties Colorless liq., pungent menthol odor misc. with most soivs., ethanol, butanol, acetone, ether, benzene insol. in water m.w. 132.21 dens. 0.981 (13 C) vapor pressure 1 mm (38 C) m.p. -25 C b.p. 206 C flash pt. 160 F ref. index 1.5410 Toxicology LD50 (oral, rat) 2860 mg/kg, (dermal, rabbit) 17 g/kg mod. toxic by ing. mildly toxic by skin contact primary irritant to eyes, mucous membranes, respiratory system severe skin irritant narcotic in high cones. may cause cataracts, kidney damage tumorigen TSCA listed... 

MC principally affects the CNS, where it acts as a narcotic. The obsen/ation of the symptoms characteristic of CNS depression, along with a physical examination, provides the best detection of early neurological disorders. Since exposure to MC also increases the carboxyhemo-globin level in the blood, ambient carbon monoxide levels would have an additive effect on that carboxyhemoglobin level. Based on such information, a periodic post-shift carboxyhemoglobin test as an index of the presence of carbon monoxide in the blood is recommended, but not required, for medical surveillance. 

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