In vitro pharmacological profiling

Hidaka, K, Tada, S, Matsumoto, M, Ohmori, J, Tasaki, Y, Nomura, T, Usuda, S and Yamaguchi, T (1996) In vitro pharmacological profile of YM-43611, a novel D2-like receptor antagonist with high affinity and selectivity for dopamine D3 and D4 receptors. Brit. J. Pharmacol. 117 1625-1632. 

Lung compliance in vivo Ciliary beat assays in vitro Mucus level assays in vitro Alveolar Type II cell surfactant secretion assay in vitro Pharmacological profiling — binding or functional assays at receptors, enzymes, ion channels, transporters... 

Identification of compounds with similar in vitro pharmacological profiles using clustering... 

Whitebread, S., Hamon, J., Scheiber, J., Fekete, A., Azzaoui, K., Mikhailov, D., Lu, Q. and Urban, L. (2008) Broad-scale in vitro pharmacology profiling to predict clinical adverse effects. American Drug Discovery,... 

In the patent literature [103], i.v. administration of twin drug 47 consisting of the p antagonist (S-naltrexamine (28) [71] and the selective 8 antagonist NTI (5) [9-11] pharmacophores was reported to reduce plasma glucose levels. Unfortunately, there have been no descriptions of the in vitro pharmacological profiles (Fig. 12). 

The characterization of the in vitro pharmacological profile of SR 120819A is illustrated here in two relevant well-known Y1-receptor preparations the human neuroblastoma SK-N-MC cell line (Fuhlendorff el al., 1990 Feth et al., 1991) and the rabbit vas deferens (Doods and Krause, 1991). 

Bowes, J., Brown, A.J., Hamon, J., Jarohmek, W., Sridhar, A., Waldron, G., Whitebread, S. (2012). Reducing safety-related dmg attrition the use of in vitro pharmacological profiling. Nature Reviews in Drug Discovery, 11, 909-922. 

Bowes J, Brown A, Hamon J, Jarolimek W, Sirdhar A, Waldron G, Whitebread S (2012) Reducing safety-related drug attrition the use of in vitro pharmacological profiling. Nat Rev Drug Discov 11 909-922. 

Finally, both fexofenadine and its sila-bioisostere exhibited similar in vitro pharmacological profiles. Evaluation of the effects in vivo of the C/Si switch, though, was not reported. 

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