American Drug

It was with this quotation from Cuatresecas that I closed my previous work on industrial HPLC,2 and it was the inspiration to write this book. Cuatresecas rightly refutes the misconception that dedication, quality, vision, trust, and honesty are inimical to profit. By historical accident, the American drug industry was driven by regulation to develop quality standards at a period in time when other segments of industry were degrading their scientific... 

LC Lappas. The manufacture of hard gelatin capsules, paper presented to Research and Development Section, The American Drug Manufacturers Association, Atlantic City, NJ, October 8, 1954. 

Herty s editorial closed by soliciting comments from the readership. He received at least a few letters, but recognized the need to be more aggressive in promoting discussion of the subject. Herty thus arranged for the November 8, 1918, meeting of the New York Section of the American Chemical Society, which he served as Chairman, to be devoted to the topic (20). Seven prominent individuals spoke to the need for an institute for cooperative research as an aid to the American drug industry. 

Whitebread, S., Hamon, J., Scheiber, J., Fekete, A., Azzaoui, K., Mikhailov, D., Lu, Q. and Urban, L. (2008) Broad-scale in vitro pharmacology profiling to predict clinical adverse effects. American Drug Discovery,... 

O Brien, P.J. and Domingos, M.C. (2009) Use of high content analysis in toxicologic clinical pathology for identification and monitoring of translational safety biomarkers. American Drug Discovery... 

Wolfe SM. Why do American drug companies spend more than 12 billion a year pushing drugs J Gen Intern Med 1996 11 637-639. 

CICAD Inter-American Drug Abuse Control Commission... 

Billups. N.F. and S.M. Billups American Drug Index 2000, 44lh Edilion. Facts And Comparisons. St. Louis. MO. 1999. 

The 1950s marked the end of a phase of American drug policy regarding marijuana. The century had begun with limited concern about marijuana by the 1950s, harsh penalties had been adopted on both the federal and state levels for its possession, use, or sale. By the end of the 1950s, many states had passed laws that made the possession of even small amounts of marijuana subject to the same penalties as for those who had committed violent crimes. 

Eventually, 100,000 units of penicillin were produced by a consortium of American drug companies (Merck, Squibb, and Pfizer) by the middle of 1944. A tremendous improvement in yield was made possible by the use of a new strain of mold, as well as the use of deep fermentation tanks similar to those used in the brewery industry. Interestingly, the new strain of mold discovered was serendipitously found on a decaying cantaloupe in a Peoria food market. 

C. O. Wilson and T. E. Jones, American Drug Index. Pitman Medical Publ., London, 1969. 

Likewise, Berkeley Professor, Peter Dale Scott, author of Cocaine Politics Drugs, Armies and the CIA in Central America, exhaustively details CIA knowledge of and complicity in protecting Latin American drug lords. 

To this end, the committee members drew up a letter and questionnaire soliciting the help of all of the above cited agencies in addition to the National Research Council physicists and chemists, members of the American Drug Manufacturers Association, United States Pharmacopoeia, National Formulary, Bureau of Chemistry of the Association of Official Agricultural Chemists, teachers in the leading college of pharmacy, etc. In all, 700 questionnaires were sent out. Of these 700, only 52 answers were received while 13 stated they "...were not interested in the problem."... 

The compendia cited give the composition of drugs and the chemical identity of their ingredients. Especially useful for this purpose are The American Drug Index and The Merck Index, the latter being international in scope. 

Car BD. Enabling technologies in reducing drug attrition due to safety failures. American Drug Discov 2006 1 53-56. 

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