Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Twin drugs

The search for cationic cholinergic agents has led to numerous twin drugs (Fig. 1.10). The bis-quatemary ammonium salts hexamethonium and decamethonium are potent blockers in ganglia and in neuromuscular junctions, respectively. Other [Pg.9]

Other examples of twin drugs are the antioxidant probucol, which lowers the cholesterol level in blood, and cromolyn, a chromone heterocycle, which is useful in the inhalational treatment of bronchial asthma (Fig. 1.11). [Pg.10]


As mentioned above, the twin drug 72 (Fig. 19) was also prepared from naltrexone (1) and showed s receptor antagonist activity [88], In the course of the synthetic investigation of 72, we unexpectedly obtained a triplet drug 73 with a 1,3,5-trioxazatriquinane skeleton (red color in Fig. 19). [Pg.215]

Keywords Dual action Increment of potency Receptor dimerization Twin drug Triplet drug... [Pg.239]

Twin Drugs Consisting of Opioid and the Other Pharmacophores. 258... [Pg.240]

Excellent reviews about twin drugs with opioid pharmacophores have been published [25-27], including those that discuss peptidic twin drugs [27-29]. The following chapter will mainly focus on the twin and triplet drugs whose in vivo pharmacological effects have been evaluated, and will include a description of their pharmacology and synthesis. [Pg.243]

Table 1 Binding affinities of cyclorphan (6), butorphan (7), twin drugs 12, 13, and 15-17 to the opioid receptors... Table 1 Binding affinities of cyclorphan (6), butorphan (7), twin drugs 12, 13, and 15-17 to the opioid receptors...
Fig. 7 Structures of nalbuphine (22), naltrexone (23), naloxone (24), and twin drugs 25-27... Fig. 7 Structures of nalbuphine (22), naltrexone (23), naloxone (24), and twin drugs 25-27...
Tethering the selective 8 antagonist NTI (5) [9-11] with the Kj agonist ICI 199,441 (43) [88] gave the KDAN series of twin drugs 44 (Fig. 10) [89]. Twin drugs 44 were synthesized in a similar manner to the synthesis of compound 30. In the... [Pg.253]

In the patent literature [103], i.v. administration of twin drug 47 consisting of the p antagonist (S-naltrexamine (28) [71] and the selective 8 antagonist NTI (5) [9-11] pharmacophores was reported to reduce plasma glucose levels. Unfortunately, there have been no descriptions of the in vitro pharmacological profiles (Fig. 12). [Pg.256]

Although most of recently reported twin drugs are nonsymmetrical, symmetrical versions have also been reported. [Pg.257]


See other pages where Twin drugs is mentioned: [Pg.3]    [Pg.9]    [Pg.10]    [Pg.10]    [Pg.10]    [Pg.221]    [Pg.223]    [Pg.239]    [Pg.239]    [Pg.239]    [Pg.241]    [Pg.241]    [Pg.241]    [Pg.242]    [Pg.242]    [Pg.243]    [Pg.243]    [Pg.243]    [Pg.244]    [Pg.246]    [Pg.246]    [Pg.247]    [Pg.248]    [Pg.248]    [Pg.248]    [Pg.248]    [Pg.248]    [Pg.251]    [Pg.251]    [Pg.252]    [Pg.253]    [Pg.254]    [Pg.255]    [Pg.256]    [Pg.256]    [Pg.257]    [Pg.257]    [Pg.257]   
See also in sourсe #XX -- [ Pg.3 ]

See also in sourсe #XX -- [ Pg.239 , Pg.258 ]

See also in sourсe #XX -- [ Pg.252 ]

See also in sourсe #XX -- [ Pg.239 , Pg.258 ]




SEARCH



Binding mode analysis identical twin drugs

Cholinergic twin drugs

Enzyme inhibitors twin drugs

Homo and Heterodimer Ligands the Twin Drug Approach

Identical twin drugs

Identical twin drugs receptor ligands

Non-identical twin drugs

Twin drug approach

Twin drug approach heterodimer ligands

Twin drugs receptor ligands

© 2024 chempedia.info