Importance in human health

B. Bagchi, M. Bagchi, S.J. Stohs, D.K. Das, S.D. Ray, C.A. Kuszynski, S.S. Joshi and H.G. Pruess, Free radicals and grape seed proanthocyanidin extract importance in human health and disease prevention. Toxicology 148 (2000) 187-197. 

Odors affect human behavior more than we realize. They are now appreciated as important in human health and disease. Above all, the powerful role of learning is impressive. Odors become associated with pleasant and unpleasant experiences and can retain their hedonic value lifelong. This applies to food, to social and sexual relationships, and to environments such as houses, workplaces, or landscapes. Writers rather than scientists have described such anecdotes. In Remembrances of Things Past, Marcel Proust evoked a flood of childhood memories by the taste of a madeleine dipped in lime-blossom tea. Jean-Paul Sartre tells in his autobiography Les Mots how the halitosis of his grade-school teacher became to him the odor of authority. 

TEicosanoids are paracrine hormones, substances that act only on cells near the point of hormone synthesis instead of being transported in the blood to act on cells in other tissues or organs. These fatty acid derivatives have a variety of dramatic effects on vertebrate tissues. They are known to be involved in reproductive function in the inflammation, fever, and pain associated with injury or disease in the formation of blood clots and the regulation of blood pressure in gastric acid secretion and in a variety of other processes important in human health or disease. 

Lipid oxidation is an important topic in food science and technology since the reaction of polyunsaturated fatty acids with oxygen leads to rancidity and quality loss. The same process is important in human health, since the polyunsaturated fatty acids from lipids present in blood plasma (low density lipoproteins, LDL) are oxidised by oxygen in a free radical mediated reaction, promoting the development of atherosclerosis. LDL enters the arterial wall from the plasma and is oxidised locally within the wall by oxidising agents derived from the cells present in atherosclerotic... 

Bagchi, D. et al.. Free radicals and grape seed proanthocyanidin extract importance in human health and disease prevention. Toxicology, 148, 187, 2000. 

These enzymes continue to be the subject of intense research efforts, and this is a direct result of their unusual geometric and electronic structures, their key roles in the global C, N and S cycles, their pharmacological importance, and their importance in human health. This volume will detail how spectroscopy, structure, electrochemistry and theory have been used to develop a comprehensive description of the active site electronic structure contributions to reactivity in pyranopterin Mo enzymes and the Mo-dependent nitrogenase. A particular emphasis is placed on how these important studies have been used to reveal critical components of enzyme mechanisms. 

All radiations are Important, but the discussion that follows will be limited to ultraviolet light because of its importance in human health and nutrition. 

Monounsaturated and polyunsaturated fatty acids are extraordinarily important in human health and nutrition. Thus, the insertion of double bonds into the carbon skeleton of a fatty acid is a vital metabolic function. However, humans are in general not capable of inserting double bonds closer than nine carbon atoms from the methyl end of a fatty acid. Thus, we are incapable of the de novo synthesis of... 

Organoarsenic compounds have been of importance in human toxicology but have not as yet received much attention in regard to environmental effects. Like methyl mercury compounds, they are both synthesized in the environment from inorganic forms and released into the environment as a consequence of human activity (Environmental Health Criteria 18). They can cause neurotoxicity. 

Vitamin A (retinol) and retinoic acid are carotenoid oxidation compounds that are very important for human health. The main functions of retinoids relate to vision and cellular differentiation. With the exception of retinoids, it was only about 10 years ago that other carotenoid oxidation products were first thought to possibly exert biological effects in humans and were implicated in the prevention - or promotion of degenerative diseases. A review on this subject was recently published. ... 

RESEARCH UNIVERSITIES ARE IN THE MIDST OF MAJOR CHANGE. Historically, the research universities have been supported by the Government with two theories in mind (1) national security is important, and science and technology are critical to a strong defense and (2) human health is important. The interest in human health persists, an interest in national security persists, but the adversary has given up. The Soviet Union no longer exists. The question now is, What is the rationale for the support of universities—support in the post-Cold War era The Department of Defense, which has nurtured an important set of activities, has a role in electronics and devices, structural materials, and high-performance or advanced-performance materials. 

The most significant difference in human health indicators between the experimental and control villages was in Uzbekistan (with 18 indicators), Armenia (13 indicators), Azerbaijan and rice growing regions of the Krasnodar Krai in Russia (11 indicators), and Moldavia (10 indicators). The lowest number of differences (with only 3-4 indicators) was detected in the Rovensk and Vinnitsk Oblasts of Ukraine. It is important to emphasize that the... 

In Unit 4, you learned that buffers resist changes in pH. Buffer systems are extremely important to human health, since many of the life-sustaining reactions in the body depend on a narrow pH range to proceed effectively. 

The obvious question about vitamins is why do we need them What is the role of each vitamin in human health and physiology What happens if we do not get sufficient amounts of a vitamin The central purposes of this chapter are to identify these vitamins chemically and to provide answers to these questions. I am not going to consider all vitamins on the list but focus on those that seem most important to understand. 

Experimental studies have identified at least 26 potential molecular targets that are affected by resveratrol. Which of these, or what combination of these, is responsible for the beneficial actions of resveratrol in experimental animals is unclear. This will be a difficult puzzle to unravel. However, if ongoing clinical studies in people establish a clear role for resveratrol or a related molecule in human health, the mechanism of action will be of secondary importance. 

Mitscherlich, E. and Marth, E. H. (1984). Microbial survival in the environment. In "Bacteria and Rickettsiae Important in Human and Animal Health" (E. Mitscherlich and... 

Considering the importance of vitamins in human health and the legislation regarding them, the analysis of these compounds appears to be very important. Indeed, vitamin assays in food... 

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