Grape seed proanthocyanidin extract

B. Bagchi, M. Bagchi, S.J. Stohs, D.K. Das, S.D. Ray, C.A. Kuszynski, S.S. Joshi and H.G. Pruess, Free radicals and grape seed proanthocyanidin extract importance in human health and disease prevention. Toxicology 148 (2000) 187-197. 

Sen, C. and Bagchi, D., Regulation of inducible adhesion molecule expression in human endotheila cells by grape seed proanthocyanidin extract. Mol. Cell Biochem., 216, 1, 2001. 

STE, 1.6-, 2.0-, and 2.7-fold increases in snperoxide anion prodnction were observed. Preincubation of the cells with vitamin C (75pM), vitamin E (75pW), a combination of vitamins C plus E (75 pA/ each), and grape seed proanthocyanidin extract (GSPE) (lOOpg/ml) for 4h decreased STE (300pg/ml)-induced cytochrome c reduction by 37, 39, 44, and 48%, respectively, as compared with the STE-trcated cells. ... 

Banerjee, B. and Bagchi, D., Beneficial effects of a novel IH636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis, Digeift on, 63 (3), 203-206, 2001. 

Apocynin and spinach leaf antioxidant extract Grape seed proanthocyanidin extract... 

Bagchi, D. et al.. Free radicals and grape seed proanthocyanidin extract importance in human health and disease prevention. Toxicology, 148, 187, 2000. 

Ray, S.D. et al.. In vivo protectiou of DNA damage associated apoptotic aud necrotic cell deaths during acetaminophen-induced uephrotoxicity, amiodaroue-iuduced luug toxicity and doxorubicin-induced cardiotoxicity by a uovel IH636 grape seed proanthocyanidin extract. Res. Comm. Mol Pathol Pharmacol, 107, 137,2000. 

Bagchi, M. et al, Acute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract, Nutrition Res., 19,1189, 1999. 

Joshi, S.S. et al., Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology, 155, 83, 2000. 

Joshi, S.S., Kuszynski, C.A., and Bagchi, D., The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract, Curr. Pharm. Biotech., 2, 187, 2001. 

Ye, X. et al.. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells, ATo/. Cell Biochem., 196, 99, 1999. 

Krohn, R.L. et al.. Differential effect of a novel grape seed proanthocyanidin extract on cultured human normal and malignant cells, in Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease, Kumpulainen, J.T. and Salonen, J.T., Eds., Royal Society of Chemistry, Cambridge, U.K., 1999, p. 443. 

Ray, S.D. et al.. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome P450 2E1-dependent aniline hydroxylation, A/o/. Cell. Biochem., 218, 27, 2001. 

Bagchi, D., Ray, S.D., Bagchi, M., Preuss, H.G., and Stohs, S.J., Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract, Indian J. Exp. Biol, 40, 717,2002. 

Ray, S.D. et al., 1H636 Grape seed proanthocyanidin extract (GSPE) exposure significantly attenuates dimethylnitrosamine (DMN)-induced liver cancer and mortality in B6C3F1 mice, Proc. Am. Assoc. Cancer Res., 41,460,2000. 

Bagchi, D., Oxygen free radical scavenging abilities of vitamins C, E, P-carotene, pycnogenol, grape seed proanthocyanidin extract, astaxanthin and BioAstin in vitro, Final Report to Cyanotech Corporation, Creighton University School of Health Sciences, Omaha, NE, 2001. 

Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ (1997) Oxygen free radical scavenging abilities of vitamins C and E, and A grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95 179-189... 

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