Immunoglobulin signal transduction

In living systems, proteins function as catalysts (enzymes), for defense (antibodies, immunoglobulins), signal transduction (hormones, receptors), metabolic regulation (hormones, enzymes, receptors, ion channels), movement (microtubules), and architecture (structural proteins such as collagen). 

Chaperones. Figure 2 The multiple roles of BiP in the biogenesis of the secretory proteins. BiP, immunoglobulin heavy chain binding protein ER, endoplasmic reticulum ERAD, ER-associated degradation ERj, resident ER protein with J-domain Sec61, core subunit of the protein translocase UPR, unfolded protein response that involves several signal transduction pathways that are activated in order to increase the biosynthetic capacity and decrease the biosynthetic burden of the ER... 

Immunoglobulin-like cell adhesion molecules signal to the cytoplasm. In some instances, adhesion may act primarily to bind membranes to surfaces but it now seems clear that some IgCAMs act via the cytoplasmic domain after engaging with a cognate partner molecule to initiate a signal-transduction cascade as a direct consequence of an adhesive interaction. A good example of this is the Trk receptors, which have two Ig domains in their... 

Brummendorf, T. and Rathjen, F. G. Axonal glycoproteins with immunoglobulin and fibronectin type II-related domains in vertebrates Structural features, binding activities and signal transduction. /. Neurochem. 61 1207-1219, 1993. 

Rosales, C., Brown, E. J. (1992). Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation on intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate. J. Biol. Chem. 267, 5265-71. 

Aplin, A.E., Howe, A., Alahari, S.K., Jiiliano, R.L. (1998) Signal transduction and signal modulation by cell adhesion receptors the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50, 197-263. 

CD3 complex of delta, epsilon, gamma, zeta and eta chains of integral membrane glycoproteins that associates with T cell antigen receptor (TCR), and is required for TCR cell surface expression and signal transduction. CDS is a universally expressed by T cells. Member of immunoglobulin superfamily. 

Adhesion molecules. Molecules, belonging mainly to the immunoglobulin or integrin superfamily of molecules (e.g. LFA-1, ICAM-1), expressed on the membrane of various cells of the immune system. Interactions with each other as receptors and corresponding ligands facilitate cooperation (cross-talk) of cells, signal transduction, and information transfer between cells. 

Juliano, R. L. 2002. Signal transduction by cell adhesion receptors and the cytoskeleton functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Ann. Rev. Pharmacol. Toxicol. 42 283-323. 

A16. Ashida, T., Kubo, K., Kawabata, I., Katagiri, M., Ogimoto, M., and Yakura, H. Signal transduction mechanisms of la induction in B cells by interleukin-4 and immunoglobulin receptors. Cell. Immunol. 126, 233-238 (1990). 

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