Dendritic cells immune response

As the main antigen-presenting cells of the adaptive immune response, dendritic cells (DCs) play a crucial role in regulation and activation of adaptive immrmity (Steinman Banchereau, 2007). Under homeostatic conditions, DCs reside in peripheral tissues and continuously scan their... 

NF-kB regulates both innate and adaptive immune responses ( immune defense) [2]. Understanding the function of NF-kB in the development, maintenance, and activation of cells from the immune system (including hematopoietic cells, macrophages, dendritic cells, B and T lymphocytes) has greatly benefited from the analysis of knockout mice in which individual NF-kB family members were defective. 

Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin- 10-treated dendritic cells and transforming growth factor-p for their induction. Clin Exp Allergy 2006 36 1546-1555. 

Cook DN, Prosser DM, Forster R, et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 2000 12(5) 495-503. 

FIGURE 9.2 Regulation of Immunity by lnterleukin-2 (IL-2). IL-2 production by T cells and DCs supports the proliferation of T cells, B cells, T reg cells, and NK cells, in addition to establishing a bias towards a Type 1 T cell response. IL-2 can also activate monocytes and NK cells, resulting in increased cytotoxicity. DC dendritic cell IL-2 interleukin-2 NK natural killer cell. 

Ou-Yang, P. et al., Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine Role of dendritic cells, J. Med. Virol., 66, 320, 2002. 

Ingested arsenic localizes to the skin [2, 7], where it may alter cutaneous immune responses. The delayed type hypersensitivity (DTH) response to 2,4-dinitrochlorobenzene (DNCB) was suppressed in Bowen s disease patients [8], Langerhans cells (LC) in skin lesions and perilesioned skin from arsenic-induced Bowen s disease and carcinomas were reduced in number and were morphologically altered, having a notable loss of dendrites [9], These data suggest that chronic exposure to arsenic in drinking water may... 

Robbins, C.S., et al., Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness, Am. J. Respir. Cell. Mol. Biol. 30, 2, 202, 2004. 

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