Immune Rebound

In 12 hours, all elements had returned to a level above the pretreatment level, particularly the white cells. This Immune Rebound Phenomenon, a phrase coined by Dr. Farr, indicates a strong stimulation of the immune (defense) system. This helps explain why the H202 treatments are effective in all types of infectious diseases, i.e., influenza, allergies, Candida, Ebstein-Barr, CMV, herpes, etc. Dr. Farr and his group are currently studying the effects of H202 in AIDS, hepatitis, encephalitis, and other serious viral diseases. Repeated infusions, as often as... 

In a placebo-controlled study of chemoprophylaxis for malaria, 701 Tanzanian infants were assigned to intermittent pyrimethamine + sulfadoxine (under 5 kg, a quarter of a tablet 5-10 kg, half a tablet over 10 kg, one tablet each tablet contained pyrimethamine 25 mg plus sulfadoxine 500 mg) alongside routine childhood immunizations and iron supplementation at 2, 3, and 9 months of age (4). The combination was well tolerated, with no reported adverse events. Episodes of clinical malaria fell by 59% (95% Cl = 41, 72) and the incidence of severe anemia by 50% (95% Cl = 8, 73%) in the first year of life. Contrary to previous studies involving continuous prophylaxis in infants, there was no increase in the frequency of rebound episodes of malaria up to 18 months of age, suggesting that the development of malaria-specific immunity was unimpaired. Responses to vaccines were unaffected. 

Two types of thrombocytopenia associated with heparin use have been described. " As many as of 25% of patients receiving heparin therapy develop a benign, mild reduction in platelet counts referred to as non-immune-mediated heparin-associated thrombocytopenia (HAT) or previously called HIT type 1. HAT produces a transient fall in platelet count that occurs early, typically between days 2 and 4, during the course of therapy. The degree of thrombocytopenia is usually mild, with platelet counts rarely going below 100,000/mm . It is not necessary to discontinue heparin therapy in these patients because platelet counts generally rebound to baseline values despite continued use. The exact mechanism of HAT is unknown, but it may be the result of platelet aggregation, a dilutional effect, or diminished platelet... 

Not to be overlooked is vitamin C, as previously described, and the work of Cameron and Pauling (1993), and of Hoffer (2000). Separate chapters are contained in both Moss (1992) and Pelton and Overholser (1994). The controvCTsy over the Mayo Clinic studies is reviewed objectively, and it is stressed that vitamin C works only if the immune system has not been damaged by chemotherapy. Moreover, there is said to be a rebound effect with vitamin C, whereby a sudden stoppage severely depletes the blood serum levels. The patient should be taken off slowly. 

An extension of indirect response models are precursor pool-dependent indirect response models that include the lihera-tion of an endogenous compound from a storage pool. These models possess the unique ability to characterize hoth tolerance and rebound phenomena [90]. Such a model was, for example, used to describe the effect of interferon- Sla on neopterin, an endogenous marker for cell-mediated immunity, in humans and monkeys (Fig. 8) [91, 92]. The primary elimination mechanism of interferon- 8 la was modeled as receptor-mediated endo-cytosis, and the pharmacodynamic model was driven by the amount of internalized drug-receptor complex DR ... 

Immune reconstitution inflammatory syndrome is a reported rebound phenomenon after withdrawal of natalizumab [252, 253 ]. 

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