Perphenazine Imipramine

Simultaneous amitriptyline, benactyzine, buclizine, desipramine, hydroxyzine, imipramine, perphenazine, protriptyline, thioridazine... 

Radwanska, A. Frackowiak, T. Ibrahim, H. Aubry, A.-F. Kaliszan, R. Chromatographic mcxlelling of interactions between melanin and phenothiazine and dibenzapine drugs. Biomed.Chromatogr., 1995, 9, 233-237 [also acetopromazine, chlorpromazine, clomipramine, ethopromazine, fluphenazine, imipramine, perphenazine, prcxihlorperazine, promazine, propiomazine, thioridazine, trifluoperazine, tri-fluopromazine, trimeprazine]... 

A collaborative VA study (364) found that the addition of imipramine or a monoamine oxidase inhibitor to CPZ did not benefit chronic psychotic patients any more than CPZ alone. Further, the addition of an amphetamine was slightly harmful. This finding has since been replicated in several studies on apathetic schizophrenic patients (365). A study of chronic ambulatory schizophrenics compared amitriptyline plus perphenazine with perphenazine alone ( 366). While they found the combination slightly better in ameliorating depressive symptoms, it was at the cost of a slight increase in patients thought disorder. 

Berger and Wilson also reported the separation of 10 antidepressants (amitriptyline, imipramine, nortriptyline, desipramine, protripyline, bucliz-ine, benactyzine, hydroxyzine, perphenazine, and thioridazine) using a packed-column SFC with a tertiary mobile phase [37], A Lichrosphere cyanopropyl column with a mobile phase consisting of supercritical fluid carbon dioxide with 10% modifier (methanol with 0.5% isopropylamine) was used for the separation. It was noted that solutes did not elute without the addition of isopropylamine. Detection limits obtained were as low as 88 ppb for a 5-jul injection. 

CYP2D6 Antidepressants amitriptyline, clomipramine, imipramine, desipramine, nortriptyline, trimipramine, N-desmethyl-clomipramine, fluoxetine, norfluoxetine, paroxetine, venlafaxine, sertraline Neuroleptics chlorpromazine, thioridazine, perphenazine, haloperidol, reduced haloperidol, risperidone, clozapine, sertindole Others codeine, opiate, propranolol, dextromethorphan 4 no activity 25% in Caucasians 0%-10% in others 5 no activity 2%-10% in all groups 10 reduced activity 47%-70% in Asians <5% in others 17 reduced activity 25%-40% in blacks 0% in others 2XN increased activity 19%-29% in Arabs and Ethiopians <5% in others... 

Clinically important, potentially hazardous interactions with amiodarone, amisulpride, amitriptyline, amoxapine, arsenic, bepridil, bretylium, calcium, chlorpromazine, clomipramine, desipramine, disopyramide, doxepin, erythromycin, fluphenazine, imipramine, iron salts, magnesium, mesoridazine, nortriptyline, pentamidine, perphenazine, phenothiazines, pimozide, procainamide, prochlorperazine, promazine, promethazine, protriptyline, quinidine, sotalol, sucralfate, thioridazine, tricyclic antidepressants, trifluoperazine, trimipramine, zinc salts... 

Opipramol (Ensidon). In an effort to impart antianxiety properties to the imipramine molecule, Schindler and Blattner (94) incorporated the perphenazine side chain (piperazinoethanol) into the unsaturated form (iminostilbene) of imipramine ... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Simultaneous alprazolam, chlorpromazine, chlorprothixene, clomipramine, desmethyli-mipramine, diazepam, flunitrazepam, fluphenazine, haloperidol, imipramine, maproti-line, perphenazine, promethazine, protriptyline, thioridazine, thioridazine sulfone, thioridazine sulfoxide, zimeldine, zuclopenthixol... 

Simultaneous benactyzine, buclizine, hydroxyzine, perphenazine, thioridazine, desipra-mine, imipramine, nortriptyline, protriptyline... 

Wong, S.H.Y. McHugh, S.L. Dolan, J. Cohen, K.A. Tricyclic antidepressant analysis by reversed-phase liquid chromatography using phenyl columns. J.Liq.Chromatogr., 1986, 9, 2511-2538 [also acetaminophen, amobarbital, amoxapine, barbital, chlordiazepoxide, chlorpromazine, cimetidine, clomipramine, codeine, desipramine, desmethyldoxepin, diazepam, doxepin, fluphenazine, flurazepam, glutethimide, hydroxyamoxapine, imipramine, lorazepam, maprotiline, meperidine, metabolites, nortriptyline, oxazepam, pentobarbital, perphenazine, phenobarbital, phenytoin, propoxyphene, protriptyline, secobarbital, thioridazine, trazodone]... 

Extracted amitriptyline, chlordiazepoxide, chlorpromeizine, desipramine, desmethldiaze-pam, desmethylchlordiazepoxide, desmethyldoxepin, doxepin, fluphenazine, haloperidol, nortriptyline, oxazepam, thiothixene Noninterfering molindone, perphenazine, trifluoperazine Interfering imipramine... 

Also analyzed acetaminophen, alprazolam, amitriptyline, amoxapine, carbamazepine, chlordiazepoxide, chlorpromazine, chlorprothixene, clonazepam, demoxepam, desipra-mine, diphenhydreiniine, disop3n amide, doxepin, ethotoin, durazepam, glutethimide, hal-operidol, haloperidol, imipramine, lidocaine, lorazepam, loxapine, maprotiline, mesantoin, mesoridetzine, methaqualone, methotrimeprazine, nordiazepam, nortriptyline, oxazepam, pentazocine, perphenazine, phenacetin, phenobarbital, phen3doin, promazine, promethazine, propranolol, protriptyline, salicylic acid, thiothixene, trifluoperazine, trifluproma-zine, trimipramine... 

Simultaneous amitriptyline, caffeine, carbamazepine, chlordiazepoxide, chlorpromazine, clonazepam, desipramine, flunitrazepam, flimazepam, haloperidol, imipramine, levome-promazine, maprotiline, mianserin, nitrazepam, nortriptyhne, perphenazine, phenobar-bital, phen5d oin, sulpride, thioridazine, triazolam... 

Simultaneous amoxapine, chlordiazepoxide, chlorpromazine, cimetidine, desipramine, diazepam, doxepin, flurazepam, imipramine, lorazepam, norfluoxetine, nortriptyline, oxazepam, pentobarbital, perphenazine, phenobarbital, phen5doin, prochlorperazine, secobarbital, thioridazine, trifluoperazine Noninterfering acetaminophen, codeine, meperidine Interfering amitriptyline, propo q>hene... 

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