Imaging angiogenesis cancer

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Leach MO (2001) Application of magnetic resonance imaging to angiogenesis in breast cancer. Breast Cancer Res... 

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Goh V, Halligan S, Bartram Cl (2007) Quantitative tumor perfusion assessment with multidetector CT are measurements from two commercial software packages interchangeable Radiology 242 777-782 Goh V, Padhani AR, Rasheed S (2007) Functional imaging of colorectal cancer angiogenesis. Lancet Oncol 8 245-255... 

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Expression and secretion of proteases by the tumor microenvironment is critical both for support of tumor progression and metastasis, activation of growth factors and promotion of angiogenesis and invasion by digestion of the extracellular matrix (matrix metalloproteinases, MMPs, are collagenases) [114], The dominant cancer proteases are cathepsins and MMPs with both extracellular secreted MMPs and membrane type MMPs (MT-MMPs). This has promoted the use of cathepsin and MMP substrate peptides for tumor imaging and/or therapy [ 115,116]. 

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