Testosterone glucuronidation

Zebra danio Testosterone glucuronide and Attracts males van denHurketfl/.,... 

TC = testosterone glucuronide E3 16G = e8terlol-16a(B-D-glucur-onlde). (Reproduced with permission from Ref. Copyright 1981,... 

The differentiation of normal from abnormal concentrations of plasma testosterone in women requires the use of either electron-capture GLC, isotopic-displacement methods, double-isotope methods, or fluorometric methods. Evidence to date suggests that the isotopic-displacement method is preferable (K3, M3). Existing fluorometric methods are adequate in analytical characteristics, but much more laborious (F2). This differentiation is crucial in cases of simple, provisionally idiopathic, hirsutism (cf. however. Cl). In many cases, however, an elevated excretion of urinary testosterone glucuronide would be equally satisfactory despite the uncertainty of its metabolic precursors (B2, II). This measurement is also desirable in cases of provisionally idiopathic amenorrhea. 

Testicular or ovarian androgen in conjuction form may be responsible for sex attractant behavior in several species of teleosts (90, 94), The sex attractant secreted by female zebrafish is a mixture of estradiol and testosterone glucuronides 388) the female guppy Poecilia reticulata is also under hormonal control 389),... 

Side chain splitting in the absence of or after hydrox-ylation in position 11 results in an overall increase in 17-ketosteroids, some of which are biologically active (androstenedione, 11 jS-hydroxyandrostene-dione, dehydroepiandrosterone) and are responsible for the virilizing symptoms. Whether or not testosterone is formed in excess in patients with the adrenogenital syndrome is not certain. High levels of testosterone glucuronide have been found in some patients with adrenal hyperplasia. 

Testosterone glucuronide can be converted directly into 5/8-androstane-3a,17/3-diol 17-glucuronide (Robel et al., 1966a), and as no 5a reduced... 

Fig. 14. Compartmentalization of testosterone glucuronide at the subcellular level, sol, soluble 5p, 3-oxo-5 -steroid-A -dehydrogenase 5a, 3-oxo 5a-steroid-M-dehy-drogenase er, endoplasmic reticulum mic, microsomes T, testosterone TG, testosterone glucuronide.

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