Hypoxia-inducible gene

Gracey, A.Y., J.V. Troll and G.N. Somero (2001). Hypoxia-induced gene expression profiling in the euroxic fish Gillichthys mirabilis. Proc. Natl. Acad. Sci. USA, 98 1993-1998. 

Tanaka H, Cao YH, Berkenstam A, Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene 49. expression. Nature 2001 414 550-554. 

HIF-1a moves to nucleus forms dimer with ARNT thereafter binding to hypoxia response elements (HRE) in the control region of hypoxia-inducible gene... 

HIF-1 binding to the control regions of the hypoxia-inducible gene is associated with recruitment of transcriptional coactivators whereafter gene transcription is stimulated... 

Liu Q, Berchner-Pfannschmidt U, Moller U, Brecht M, Wotzlaw C, et al. 2004. A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Proc Natl Acad Sci USA 101 4302-4307. 

Discovery Pladienolides are 12-membered macrohdes isolated as an antitumor substance by cell-based hypoxia-induced gene expression assay from Streptomyces platensis Mer-11107 [1]. The structures of pladienolide B and D were determined as 1 and 2, respectively [2,3]. Total synthesis of pladienolide B [4] and biosynthetic gene cluster [5] is also reported. 

Iliopoulos O, Levy AP, Jiang C, et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA. 1996 93 10595. 

HBS helices have proven to be remarkably effective tools for the regulation of protein interactions. Significantly, HBS helices outperform their unconstrained counterparts in cell culture studies reflecting their enhanced metabolic stability and cellular uptake properties. The potential of HBS helices has been demonstrated with inhibitors designed to modulate HIV fusion [35], transcription of hypoxia inducible genes [54], p53/HDM2 [33], and Ras/Sos interactions [134]. The selected examples below highlight the potential of HBS helices as inhibitors of PPIs. 

Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Leger J, Corvol P, Germain S. 2006. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. FEES Lett 580 3395-3400. 

Metzen E, Fandrey J, Jelkmatm W. Evidence against a major role for Ca in hypoxia-induced gene expression in human hepatoma cells (Hep3B). J Physiol (Lond) 1999 517(Pt 3) 651-657. 

Alfianca A, Gutierrez MD, Vara A, Aragones J, Vidal F, Landazuri MO. c-Jun and h q5oxia inducible factor functionally cooperate in hypoxia induced gene transcription. Mol Cell Biol 2002 22 12-22. 

Solomon IC, Edelman NH, Neubauer JA. Pre-Botzinger complex functions as a central hypoxia chemosensor for respiration in vivo. J Neurophysiol 2000 83 2854—2868. Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature 2001 413 171-174. Fandrey J. Hypoxia-inducible gene expression. Respir Physiol 1995 101 1-10. Semenza GL. Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. J Lab Clin Med 1998 131 207-214. 

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