Hypoxia gene expression

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HIF as master regulator of hypoxia responsive gene expression... 

Gilbert RW, Costain WJ, Blanchard ME, Mullen K, Currie RW, et al. 2003. DNA microarray analysis of hippocampal gene expression measured 12 hours after hypoxia-ischemia in the mouse. J Cereb Blood Flow Metabol 23 1195. 

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Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94(15) 8104—8109... 

Physical (e.g., heat shock, ionizing radiation) and physiological (e.g., hypoxia) stresses, along with metabolic factors (e.g., glucose), induce specific gene expression by mechanisms involving DNA sequence specific transcription factors (Table 2.1). 

Das, D.K., Maulik, N., and Moraru, 1.1. 1995. Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, hyperthermia and oxidative stress. J. Mol. Cell. Cardiol. 27 181-193,... 

Yamagata, K., Tagami, M., Ikeda, K., Yamori, Y., and Nara, Y. 2000. Altered gene expressions during hypoxia and reoxygenation in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Neurosci. Lett. 284 131-134. 

In overview, the hypoxia-sensitive expression of each of these kinds of proteins (EPO, PGK, and LDH), and of other glycolytic enzymes appears to be two-step or two-cycle systems (figure 3.14) the first cycles involve the constitutive expression of key hypoxia-sensitive transcription factors such as HIF 1 and Sp3, while the second cycles of gene expression are mediated by these transcription factors and regulate the biosynthesis of EPO, PGK, LDH, other glycolytic enzymes, and other hypoxia-sensitive gene products. 

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