Hyperlipidemia metabolic studies

The metabolic effects of indapamide appear to be as common as those of thiazides (SEDA-14, 185 SEDA-15, 216). The metabolic effects of hydrochlorothiazide 25 mg/day and indapamide 2.5 mg/day for 6 months have been compared in a randomized, double-blind study in 44 patients with mild to moderate hypertension (485). There was little difference between the effects of the drugs on a wide range of lipid parameters, glucose, and potassium. The purported metabolic differences with indapamide are unlikely to be of sufficient magnitude to warrant its preferential use in hyperlipidemia. 

Symptoms of hyperlipidemia and the metabolic syndrome have been investigated in a cross-sectional study... 

Although the data are not conclusive, hyperlipidemia has been associated as a susceptibility factor for CKD in both animal and human studies. The use of lipid-lowering agents in some animal models has been found to decrease the extent of glomerular injury when both underlying renal disease and hyperlipidemia are present. Therefore the correction of lipid abnormalities in patients with CKD was proposed to have a beneficial effect on the rate of progression of the disease. CKD with or without nephrotic syndrome is frequently accompanied by abnormalities in fipoprotem metabolism. The prevalence of hyperlipidemia appears to increase as kidney function declines and with the presence of the nephrotic syndrome. ... 

Furman et al (1964) have reported studies on the metabolism of the HDL protein, labeled with P , in hyperlipemic subjects. In two patients with fat-induced familial hyperchylomicronemia, the plasma half-time values of the labeled product—1.7 and 1.9 days—were about 50% less than the normal values reported by Scanu and Hughes (1962) and Furman et al (1964). In carbohydrate-induced hyperglyceridemia where VLDL predominates, the half-time values of the radioiodinated protein were intermediate between normolipemic subjects and those with fat-induced hyperlipidemia. An association between the injected labeled... 

Vitamins Bg, B12 and folate have specific and vital functions in the metabolism a deficiency (or excess) causes specific diseases such as hyperlipidemia, hypertension, obesity or cardiovascular diseases, which are related to a modern lifestyle and common in industrialized countries. As observed in several studies, cobalamin (B12) deficiency in most cases coincides with an insufficient folate status (Ball 2006 Howard et al. 1998 Morris et al. 2007). 

Goto, Y., Hata, Y., Kumagai, A. Saito, Y., 1980, A double blind study on the effects of pantethine on hyperlipidemias. Abstracts of the 7th International Symposium on Drugs Affecting Lipid Metabolism, p.2, Milan, Italy... 

In compensation for this abnormal situation, fat is preferentially used as a sole energy source in the body. The metabolic shift to lipid utilization leads to hypertriglyceridemia accompanied by elevation of free fatty acid in blood and, in very advanced stages by elevation of ketone bodies including acetoacetate and 3-hydroxy-butyrate in blood. Increased level of CoA and acyl CoA in the diabetic rat liver was reported by Smith et al. [1]. This seems to be a metabolic response to increased utilization of fatty acid in diabetic state and suggests increased requirement for CoA in diabetic tissues. It is, therefore, interesting to study the effect of some precursors of CoA on diabetic hyperlipidemia. The present paper deals with a favorable effect of pantethine on lipid metabolism in streptozotocin diabetic rats. Pantethine treatment has been found to reduce increased levels of serum triglycerides,... 

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