Hydroxyquinoline sulphate

Hexazinone heterocyclic nitrogen, triazine Hexythiazox thiazolidine, amide Hydramethylnon heterocyclic nitrogen, pyrimidine Hydroprene dienedodecanoate 8-Hydroxyquinoline sulphate heterocyclic nitrogen, quinoline... 

Use. Potassium hydroxyquinoline sulphate is used topically in concentrations of 0.05 to 0.5%. 

It was shown by Hartley and LinnelF that potassium hydroxyquinoline sulphate is almost certainly a simple mixture of potassium sulphate and 8-hydroxyquinoline sulphate. This is substantiated by extraction of the compound with ethanol, when complete separation of the two components results. 

The 4-aminophenazone method (see under Phenol, p. 514) has been applied by Savidge to a cream containing 7-5 per cent of zinc oxide and 0 1 per cent of potassium hydroxyquinoline sulphate. 

Another terminal bidentate ligand that has been exploited occasionally in bright disazo direct dyes is the sulphated 8-hydroxyquinoline residue (5.15). On aftercoppering, fastness to light and wet tests is enhanced by hydrolysis catalysed by the copper(II) ion and formation of a bidentate 1 2 complex (Scheme 5.3). Apparently, electron withdrawal by sulphur facilitates removal of the sulphite grouping and approach of the copper(II) cation [10]. 

The traces are precipitated as a hydroxides or acids b - suiphides c - sulphates d -elements after reduction e - 8-hydroxyquinolinates f - silver salts. 

The form of the zinc 8-hydroxyquinoline (HL) complexes extracted into chloroform from aqueous solution depends critically on the anion present in aqueous solution. In the cases of nitrate, sulphate, or chloride, ZnLj is extracted and precipitates as ZnL2,-... 

Under an inert atmosphere, prepare a suspension of sodium hydride (0.96 g, 20 mmol [50 per cent in mineral oil]) in dry THF (50 mL) in a 250 mL twonecked round-bottomed flask fitted with a reflux condenser and pressure equalized addition funnel. Stir for 30 min under an inert atmosphere. Slowly add a solution of 8-hydroxyquinoline (2.90 g, 20 mmol) in dry THF (50 mL) to this through the addition funnel. Make up a solution of triethylene glycol ditosylate, 2, (4.60 g, 10 mmol) in dry THF (50 mL), ensuring that no solids remain (filter if necessary) or the addition funnel may become blocked. Once the effervescence subsides following the formation of the sodium 8-hydroxyquinolinate salt, add the ditosylate solution and reflux for 24 h. After 24 h, allow the solution to cool to room temperature, filter off the precipitated sodium tosylate and remove the THF by rotary evaporation. Dissolve the residue in dichloromethane (30 mL) and wash with distilled water (3 x 30 mL). Dry the organic phase over anhydrous sodium sulphate, filter and remove dichloromethane by rotary evaporation to give the crude product, l,9-bis(8-quinolinyloxy)-3,6-dioxanonane (4) as a pale brown oil. Further purification may be afforded by column chromatography (silica, elute with acetone/dichloromethane). 

The scope of this extensively studied intermediate has included the preparation of a number of heterocyclic structures including quinolines, benzoxazoles, phenazines, phenoxazines and thiophenaazines (ref.94). Thus, 2-amino-4-t-octylphenol undenvent the Skraup reaction by heating with glycerol containing ferrous sulphate to afford 5-t-octyl-8-hydroxyquinoline. 5-t-Octylbenzoxazole resulted by reaction of 2-amino-4-t-octylphenol in formic acid with zinc and hydrochloric acid. 

The neutral phosphatase of tobacco XD-6 cells [M-Ia] was strongly inhibited by sodium molybdate, and moderately by copper sulphate, zinc sulphate and potassium dihydrogen phosphate (Ninomiya et ah, 1977). The alkaline phosphatase of Lysobacter enzymogenes was relatively insensitive to phosphate and arsenate, but was 97% inhibited by 0.05 mM EDTA and 99% by 0.5 mM 8-hydroxyquinoline (von Tigerstrom and Stelmaschuk, 1986). Yeast phytase [Saccharomyces spp.) was greatly... 

Follow the same procedure as for zinc. Prepare a stock solution by weighing 3.4 g of the sulphate or 4.1 g of the nitrate and make up to 250 cm in a volumetric flask. Pipette 25.0 cm into a 400 cm beaker. Add 75 cm water and then gradually add 1 M sodium carbonate solution until there is a faint cloudiness. Remove this by the dropwise addition of dilute acetic acid. Warm to 60°C and dissolve in the solution 5 g purest sodium acetate. Then add 2% solution of 8-hydroxyquinoline in ethanol with stirring until a slight excess has been added. Heat the suspension to the boiling point and allow the precipitate to settle. Check for complete precipitation and filter after 10 minutes in a prepared G4 sintered crucible. Wash on the sinter with hot water and dry to constant weigh at 130°C. Calculate from the average of duplicates the concentration of cadmium in mol dm ... 

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