4-Hydroxybenzoic acid butyl ester

Hydroxybenzoic acid butyl ester Lexgard B Nipabutyl Tegosept B Trisept B Uniphen P-23-, Unisept B. 

Butyl paraben, 4-Hydroxybenzoic acid butyl ester ... 

Synonyms Butyl 4-hydroxybenzoate n-Butyl 4-hydroxybenzoate n-Butyl p-hydroxybenzoate Butyl p-hydroxybenzoate Butyl parasept 4-Hydroxybenzoic acid butyl ester p-Hydroxybenzoic acid butyl ester Parasept Definition Ester of butyl alcohol and p-hydroxybenzoic acid Empirical C11H14O3... 

Synonyms butyl p-hydroxybenzoate -butyl-paraben n-butyl-p-hydroxybenzoate butyl-4-hydroxybenzoate Butoben Butyl Cnemosept Butyl Parasept 4-hydroxybenzoic acid butyl ester Tegosept B p-hydroxybenzoic acid w-butyl ester 4-(butoxycarbo-nyl)phenol aseptoform butyl Butyl Tegosept Nipabutyl Solbrol B Preserval B SPF Tegosept Butyl Butyl Butex p-hydroxybutyl benzoate hydroxybenzoic acid butyl ester... 

Synonyms Benzoic acid, 2-hydroxy-, butyl ester n-Butyl o-hydroxybenzoate Butyl o-hydroxybenzoate n-Butyl salicylate 2-Hydroxybenzoic acid, butyl ester Salicylic acid n-butyl ester Empirical C11H14O3 Properties M.w. 194.23 Uses Synthetic flavoring agent in foods fragrance in cosmetics Regulatory FEMA GRAS Manuf./Distrib. ICN Biomed. Research Prods. http //www.icnbiomed.com] Indofine http //www.indofinechemicai.com] TCI Am. http //www.tciamerica. com... 

Hydroxybenzoic acid, 4 (acetylamino) phenyl-, ester. See Acetaminosalol 2-Hydroxybenzoic acid, 2-[bis-(2-hydroxyethyl) amino] ethanol. See TEA-salicylate 2-Hydroxybenzoic acid bismuth (3+) salt basic. See Bismuth subsalicylate 2-Hydroxybenzoic acid, butyl ester. See Butyl salicylate... 

CAS 36457-20-2 EINECS/ELINCS 253-049-7 Synonyms Butylparaben, sodium salt p-Hydroxybenzoic acid, butyl ester, sodium salt Sodium butyl 4-hydroxybenzoate Sodium n-butyl-4-hydroxybenzoate Sodium butyl-p-hydroxybenzoate... 

Beilstein Handbook Reference) AI3-00512 Benzoic acid, 2-hydroxy-, butyl ester BRN 2208904 Brunei Butyl (2-hydroxyphenyl)formate Butyl 2-hydroxybenzoate Butyl 0-hydroxybenzoate n-Butyl o-hydroxybenzoate n-Butyl salicylate EINECS 218-142-9 FEMA No. 3650 NSC 1511 NSC 403676 Salicylic acid, butyl ester. Used as a fragrance. Liquid mp = -5.9° bp = 271° d = 1.0728 Xm = 238, 306 nm (s = 8990, 4210, MeOH) slightly soluble in CCI4. Catomance Ltd. 

Aceto. See 3,5-Di-t-butyl-p-hydroxybenzoic acid o-Acetoacetanisidide, 2-((4-chloro-2-nitrophenyl) azo)-. See Pigment yellow 73 Acetoacetic acid, butyl ester. See Butyl acetoacetate... 

Di-tert-butyl-4-hydroxybenzoic acid, hexadecyl ester... 

In comparison with the lower p-hydroxybenzoic acid alkyl esters the butyl ester is far and away the most effective one and presents an equalized spectrum of effectiveness (see Table 81). However, the application of the butyl ester as a preservative in cosmetics, toiletries and pharmaceuticals is, in spite of its high activity, limited because of its low water solubility and high log POW. But combinations of p-hydroxy-benzoic acid butyl ester with the lower alkyl esters perform excellently. 

Perfumes, Flavors, Cosmetics, and Soap. Many naturally occurring esters in essential oils and some synthetic esters are important fragrance and flavor compounds (61,62). They are used in perfumes, flavors, cosmetics, soaps, detergents, and air fresheners. Benzyl, butyl, ethyl, methyl, and phenyl esters of benzoic acid are used as flavors, perfumes, and food preservatives. Glyceryl 4-aminobenzoate [136-44-7] and 2-ethyUiexyl 4-dimethylaminobenzoate [21245-02-3] are used in cosmetic sunscreen preparations. Alkyl esters of 4-hydroxybenzoic acid, called parabens, have been used under various names for fungus infections of the skin, and as preservatives in lotions and creams (101). Soap and cosmetic fragrances use large amounts of amyl and benzyl saHcylate. Benzyl saHcylate [118-58-1] is also used in deodorant sprays. 2-Ethylhexyl saHcylate [118-60-5] and 2-ethylhexyl 4-methoxycinnamate [5466-77-3] are used in sunscreen formulations (102). 

The use of preservative eombinations may be used to extend the range and speetrum of preservation. Thus, in the series of alkyl esters of 4-hydroxybenzoic (/ -hydroxybenzoic) acid (parabens), water solubility deereases in the order methyl, ethyl, propyl and butyl ester. By eombining these produets it is possible to aehieve a situation where both the aqueous and oil phase of an emulsion are proteeted. 

Liquid dosage forms which are disperse systems (colloidal, i.e., microspheres, nanoparticles, and micelles suspensions and emulsions) often contain preservatives which are methyl, ethyl, propyl, and butyl esters of para-hydroxybenzoic acid in various combinations. A typical example is the antacid suspensions which have high pH values which make the esters of the preservatives susceptible to hydrolysis. One way to circumvent this problem is to use several preservatives in combination with the hope that some quantities of the preservatives will remain to prevent the suspension from microbial attack. A report showing the assay of the four esters and the parent acid (one of the decomposition products) in drug products in which all the preservatives were used has been given [13]. 

These compounds include the methyl, ethyl, propyl, and butyl esters of para-hydroxybenzoic acid. In the United Slates and a number of other countries, the methyl and propyl esters are preferred, while European food processors favor the ethyl and butyl esters. The parabens were first described in 1924 as having antimicrobial activity and initially were used in cosmetic and pharmaceutical products. 

Figure 6.1 UV chromatograms of the test mixture of four / -hydroxybenzoic acid esters (1, methyl 2, ethyl 3, propyl 4, butyl) after the column and after the NMR flow cell at flow rates of (a) 1.0 and (b) 0.1 ml/min conditions column, LiChrospher RP select B, 125 x 4 mm id, 5 Jim, spectrometer, Bruker DRX 600 probe head, 4 mm z-gradient LC probe, active volume 120 a1 eluents, acetonitrile (A) and D2O (B) gradient, t = Omin A/B (40/60), t = 8 min A/B (70/30) at a flow rate of 1.0 ml/min and t = 80 min A/B (70/30) at a flow rate of 0.1 ml/min...

Parabens (methyl, ethyl, propyl, and butyl esters of para-hydroxybenzoic acid) are used as preservatives in concentrations of 0.1-0.3% in pharmaceutical formulations and in concentrations of 0.01-0.1% in cosmetics and foods. In such concentrations they are devoid of systemic toxic effects, but allergic reactions have been reported. 

BHT is cleared less rapidly from most species, enterohepatic circulation being partly responsible for the delay. The major metabolites of BHT in rat urine are 3,5-di-Tbutyl-4-hydroxybenzoic acid (BHT acid III), both free (90% of the dose) and as a glucuronide (15%), and S-(3,5-di-Tbutyl-4-hydroxybenzyl)-N-acetylcysteine. The ester glucuronide and mer-capturic acid were major metabolites in rat bile, while free BHT acid was the main component in the feces. In addition, l,2-bis(3,5-di- -butyl-4-hydroxy-phenyl) ethane has been identified in rat bile. In BALB/c mice, 75% of a single oral dose was excreted in the urine during the first 24 h this was followed by a slower phase during which an additional 10% was excreted over the next 4 days. The total amount found in the feces was less than 1%. Female rats have greater urinary excretion of BHT than male rats, whereas male BALB/c mice excreted BHT more rapidly than females. 

Parabens [Napp]. TM for the methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. Antimicrobial agents for foods and pharmaceuticals. Approved by FDA as GRAS. 

Benzoic acid ethyl ester. See Ethyl benzoate Benzoic acid, 4-(((ethylphenylamino) methylene) amino)-, ethyl ester. See N-(p-Ethoxycarbony I phenyl )-N -ethy l-N -phenylformamidine Benzoic acid, hexahydro-. See Cyclohexanecarboxylic acid Benzoic acid, hexyl ester. See Hexyl benzoate Benzoic acid, 4-hydroxy- Benzoic acid, p-hydroxy-. See 4-Hydroxybenzoic acid Benzoic acid, 2-hydroxy-, butyl ester. See Butyl salicylate... 

Cyasorb UV 2337. See 2-(2 -Hydroxy-3,5 -di-t-amylphenyl) benzotriazole Cyasorb UV 2908. See 3,5-Di-t-butyl-4-hydroxybenzoic acid, n-hexadecyl ester Cyasorb UV3346 LD] Cyasorb UV3346. See N,N -Bis (2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine polymer with 2,4-dichloro-6-(4-, morpholinyl)-1,3,5,-triazine Cyasorb UV-3529. See 1,6-Hexanediamine,... 

Di-t-butyl-4-hydroxybenzoic acid, (2,4-di-t-butylphenyl) ester. See 2,4-Di-t-butylphenyl... 

Synonyms Benzoic acid, 3,5-bis (1,1-dimethylethyl)-4-hydroxy-, 2,4-bis (1,1-dimethylethyl) phenyl ester 3,5-Di-t-butyl-4-hydroxybenzoic acid, (2,4-di-t-butylphenyl) ester 3,5-Di-t-butyl-4-hydroxy (2,4-di-t-butylphenyl) benzoate Empirical C29H42O3... 

Hexadecylbetaine. See Cetyl betaine Hexadecyl chloride. See 1-Chorohexadecane n-Hexadecyl 3,5-di-t-butyl-4-hydroxybenzoate. See 3,5-Di-t-butyl-4-hydroxybenzoic acid, n-hexadecyl ester... 

Hydroxybenzoic acid 3-methyl butyl ester. See Isoamyl salicylate... 

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