2-Methoxy-4-hydroxy-6-methylbenzoic acid

Sparassol. 2-Hydroxy-4-methoxy-6-methylbenzoic acid methyl ester 4-methoxy-2,6-cresotic acid methyl ester everninic acid methyl ester orseJJinic acid methyl ester 4-methyl ether. CMH1204 mol wt 196.20. C 61.21%, H 6.17%, O 32.62%. Antibiotic substance produced by the fungus Sparassis ramose Falck, Ber. 56, 2555 (1923). Also obtained in methanol extracts of the lichen Evernla prunasti-Stenhouse, Ann. 68, 55 (1848) Spath, Jeschki, Ber. 57, 471 (1924). Structure Fischer. Hoesch, Ann. 391, 347 (1912) Wedekind. Fleischer, Ber. 56, 2556 (1923). Synthesis <3. Nicollier el at. Helv. Chim. Acta 61, 2899 (1978). [Pg.1377]

Everninic acid, 2-Hydroxy-4-methoxy-6-methylbenzoic acid (Everninsaure, 2-Hydroxy-4-methoxy-6-methylbenzoesaure)... [Pg.425]

Dioxocin. 2H,6H-l,5-Dioxocin [292-95-5], 74, 225-226, 235, 238 Dioxybenzone. 2,2 -Dihydroxy-4-methoxybenzophenone, 432 Disyringylmethane. 4,4 -Dihydroxy-3,3, 5,5 -tetramethoxydiphenylmethane, 450 Epichlorohydrin. l-Chloro-2,3-epoxypropane, 104 Ethylcellosolve. Cellosolve or 2-Ethoxyethanol, 13 Everninic acid. 2-Hydroxy-4-methoxy-6-methylbenzoic acid, 482-483 Exifone. 2,3,3, 4,4, 5 -Hexahydroxybenzophenone, 40,495-496,498, 575 9-Fluorenone. 9-Oxofluorene, 5, 57, 149,167, 280... [Pg.2882]

Methoxy-4-hydroxy-5-formyI-6-methylbenzoic acid (2-Methoxy-4-hydroxy-5-formyl-6-methylbenzoesame)... [Pg.428]

Needles (MeOH-H O), mp 163-164 °C React FeClj (EtOH) red, PD yellow Deriv Methyl 2-methoxy-4-hydroxy-5-formyl-6-methylbenzoate, needles, mp 135 °C (EtOH), from 2-methoxy-4-hydroxy-5-formyl-6-methylbenzoic acid with the calculated amount of CHjNj in EtjO at 0°C... [Pg.429]

As a typical example of tridepside synthesis, the preparation of 5-0-methylhiascic acid (227) is depicted in Scheme 35 122). Persulfate oxidation of ethyl 4-benzyloxy-2-hydroxy-6-methylbenzoate (273) in potassium hydroxide solution gave the corresponding 5-hydroxy derivative (274) from which 2,4-dibenzyloxy-5-methoxy-6-methylbenzoic acid (275) was prepared. Condensation of this acid with benzyl lecanorate (276) gave the... [Pg.157]

Hydroxy-4-0-methylgyrophoric acid 183 183-184 By condensation of 2,3-dibenzyloxy-4-methoxy-6-methylbenzoic acid and benzyl lecanorate with TFAA and subsequent debenzylation (223)... [Pg.91]

By condensation of 2,4-dibenzyloxy-6-methylbenzoic acid and benzyl 4-benzyloxy-3-(2, 4 -dihydroxy-6 -methyl-benzoyloxy)-6-hydroxy-2-methylbenzoate with TFAA and subsequent debenzylation From 4-benzyloxy-2-hydroxy-6-/i-pentylbenzoic acid and olivetol with DCCD and subsequent debenzylation From 2-hydroxy-4-methoxy-6-n-propyl-benzoic acid and divarol with DCCD From 2-hydroxy-4-methoxy-6-n-propyl-henzoic acid and 3-methoxy-5-n-propylphenol with DCCD From 4-benzyloxy-2-hydroxy-6-n-pentyl-benzoic acid and 3-methoxy-5-n-propylphenol with DCCD and subsequent debenzylation... [Pg.316]

This does not occur in the case of catalyst and reactants here described. With Bronsted-type catalysis, the reaction between the benzoyl cation, Ph-C" =0, and the hydroxy group in phenol is quicker than the electrophilic substitution in the ring. This hypothesis has been also confirmed by running the reaction between anisole and benzoic acid in this case the prevailing products were (4-methoxy)phenylmethanone (the product of para-C-benzoylation) and methylbenzoate (obtained by esterification between anisole and benzoic acid, with the co-production of phenol), with minor amounts of phenylbenzoate, phenol, 2-methylphenol and 4-methylphenol. Therefore, when the 0 atom is not available for the esterification due to the presence of the substituent, the direct C-acylation becomes the more favored reaction. [Pg.86]

Hydroxybenzo[6]thiophene has been isolated from coal tar.42 It may be prepared from 6-aminobenzo[fr]thiophene by standard procedures.241 6-Methoxybenzo[h]thiophene may be prepared by decarboxylation of the corresponding 2-carboxylic acid,341 and 6-ethoxybenzo[6]thiophene is obtained by reduction of 6-(ethoxy)-thioindoxyl (Section VI, 1,2). 6-Methoxy-5-methylbenzo[6]thiophene is obtained by cyclization of (3-methoxy-4-methylphenylthio)-acetaldehyde dimethyl acetal (Section IV,B).617 The product previously described542 as 6-hydroxy-3-phenylbenzo[6]thiophene has now been shown to be the 2-phenyl isomer.307 6-Methoxy-818 and 6-methoxy-5-methyl-benzo[6]thiophene617 are demethylated by pyridine hydrochloride. [Pg.311]

Blaser D, Stdckli-Evans H (1992) Structure of the Methyl Ester of Eveminic Acid (Methyl 2-Hydroxy-4-methoxy-6-methylbenzoate). Acta Cryst C 48 1124 Bol L, Zhongwan L, Handong S (1990) Chemical Constituents from Lobaria isidiophora. Acta Bot Yunnan 12 447... [Pg.240]

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