Hydrogen peroxide resistance

Alban PS, Krieg NR. 1998. A hydrogen peroxide resistant mutant of Spirillum volu-tans has NADH peroxidase activity but no increased oxygen tolerance. Can J Microbiol 44 87-91. 

J.R. (1990) Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance. J. Neurosci. Res. 25 360-368. 

Sugiyama M, Tsuzuki K, Haramaki N (1993) DNA single-strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide-resistant cell lines. Mutat Res 299 95-102... 

Features Nonfoaming low odor can be used in continuous bleaching operations including jet washers stable to hydrogen peroxide resistant to hard water, alkali and salts In usual cones. 

Oxidation. Disulfides are prepared commercially by two types of reactions. The first is an oxidation reaction uti1i2ing the thiol and a suitable oxidant as in equation 18 for 2,2,5,5-tetramethyl-3,4-dithiahexane. The most common oxidants are chlorine, oxygen (29), elemental sulfur, or hydrogen peroxide. Carbon tetrachloride (30) has also been used. This type of reaction is extremely exothermic. Some thiols, notably tertiary thiols and long-chain thiols, are resistant to oxidation, primarily because of steric hindrance or poor solubiUty of the oxidant in the thiol. This type of process is used in the preparation of symmetric disulfides, RSSR. The second type of reaction is the reaction of a sulfenyl haUde with a thiol (eq. 19). This process is used to prepare unsymmetric disulfides, RSSR such as 4,4-dimethyl-2,3-dithiahexane. Other methods may be found in the Hterature (28). 

Many functional groups are stable to alkaline hydrogen peroxide. Acetate esters are usually hydrolyzed under the reaction conditions although methods have been developed to prevent hydrolysis.For the preparation of the 4,5-oxiranes of desoxycorticosterone, hydrocortisone, and cortisone, the alkali-sensitive ketol side chains must be protected with a base-resistant group, e.g., the tetrahydropyranyl ether or the ethylene ketal derivative. Sodium carbonate has been used successfully as a base with unprotected ketol side chains, but it should be noted that some ketols are sensitive to sodium carbonate in the absence of hydrogen peroxide. The spiroketal side chain of the sapogenins is stable to the basic reaction conditions. 

Aluminium is used in hydrogen peroxide (H.T.P.) processing and storage equipment partly because of its high corrosion resistance but also because it does not cause degradation of the peroxide. 

Surface condition Machined, abraded and pickled surfaces all exhibit much the same behaviour in water, and after exposure of up to about one year at temperatures less than I00°C average attack measures 0 0025-0 0050mm/y. Almost always, however, corrosion of beryllium in water is accompanied by pitting and, on machined surfaces, pits of as much as 0-25mm have been observed in 0-0005M hydrogen peroxide at 85°C. Under similar conditions, annealed material has been found to be somewhat less resistant to attack than either machined or pickled surfaces. 

The majority of phosphate processes in use today are accelerated to obtain shorter treatment times and lower processing temperatures. The most common mode of acceleration is by the addition of oxidising agents such as nitrate, nitrite, chlorate and hydrogen peroxide. By this means, a processing time of 1 to 5 min can be obtained at temperatures of 43-71 °C. The resultant coatings are much smoother and thinner than those from unaccelerated processes, and, while the corrosion resistance is lower, they cause less reduction of paint gloss and are more suited to mass-production requirements. 

The introduction of chlorinated porphyrins (10) allowed for hydrogen peroxide to be used as terminal oxidant [62], These catalysts, discovered by Mansuy and coworkers, were demonstrated to resist decomposition, and efficient epoxidations of olefins were achieved when they were used together with imidazole or imidazo-lium carboxylates as additives, (Table 6.6, Entries 1 and 2). 

All attempts to oxidize either cis- or trans-di-t-butylthiirane oxides failed122 (see equation 20). Reagents investigated included m-chloroperbenzoic acid, sodium peroxide, hydrogen peroxide, ozone and aqueous potassium permanganate. The cis oxide was resistant to oxidation (apparently steric hindrance), and the trans isomer was consumed with excess oxidizing agent but no identifiable products could be isolated. 

SASPs comprise about 10-20% of the protein in the dormant spore, exist in two forms alfi and y) d are degraded during germination. They are essential for expression of spore resistance to ultraviolet radiation and also appear to be involved in resistance to some biocides, e.g. hydrogen peroxide. Spores (a /3 ) deficient in a//3-type SASPs are much more peroxide-sensitive than are wild-type (normal) spores. It has been proposed that in wild-type spores DNA is saturated with a/j3-type SASPs and is thus protected from free radical damage. 

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