Protein Based Hydrogels

C.-H. Luan and D.W. Urry, Elastic, Plastic, and Hydrogel Protein-based Polymers. In Polymer Data Handbook, J.E. Mark, Ed., 1999, Oxford University Press, New York, pp. 78-89, Tables 1 and 3a. 

Nagapudi K., Brinkman W.T., Leisen, J., Thomas B.S., Wright E.R., HaUer C., Wu X., Apkarian R.P., ConticeUo V.P., and Chaikof EU. Protein-based thermoplastic elastomers. Macromolecules, 38, 345, 2005. Petka W.A., Hardin J.L., McGrath K.P., Wirtz D., and TirreU, D.A. Reversible hydrogels from self-assembUng artificial proteins. Science, 281, 389, 1998. 

FIGURE 9.11 Relative mass change as a result of water absorption and loss in a solid piece of recombinant resilin prepared from a 20% protein solution in phosphate-buffered sahne (PBS), cross-linked using peroxidase (see [29] supplementary material). The fuUy swollen sample is designated 100. (Data courtesy of Shekibi, Y., Naim, K., Bastow, T.J., and HiU, A.J., The states of water in a protein based hydrogel. Internal CSIRO... 

Shekibi, Y., Naim, K., Bastow, T.J., and HiU, A.J., The states of water in a protein based hydrogel. Internal CSIRO report. 

Cao Y, Li HB (2008) Engineering tandem modular protein based reversible hydrogels. Chem Commun 4144 146... 

In our previous study a novel method was developed to prepare a protein-based hydrogel, i.e., a Three-Dimensional Nanos-tructured Protein Hydrogel (3-D NPH), which is composed of protein-polymer hybrid nanoparticles (19, 20). The 3-D NPH could be easily prepared by dispensing a protein and polymer mixture on a substrate. Because the analyte proteins could penetrate into the 3-D NPH, the protein array made by 3-D NPH method has tremendously improved sensitivity in detecting protein-protein interactions compared with that of the direct protein immobilization methods (2-D). 

Tanaka, H., Shiroya, T., Hanasaki, M., Iso-jima, T., Takeuchi, H., and Kawaguchi, H., (2008) Preparation of porous protein-based hydrogel for highly sensitive protein chips. Macromol. Symp., 266, 81-84. 

Tanaka,H.,Isojima,T.,Hanasaki,M.,Ifuku,Y., Takeuchi, H., Kawaguchi, H., and Shiroya, T. (2008) Porous protein-based nanoparticle hydrogel for protein chips with improved sensitivity. Macromol. Rapid Commun., 29, 1287-1292. 

Rao, J.K. Ramesh, D.V. Rao, K.P. Implantable controlled delivery systems for proteins based on collagen-pHEMA hydrogels. Biomaterials 1994, 15 (5), 383-389. 

Elastic, plastic, and hydrogel-forming protein-based polymers... 

Professor, Department of Chemical Engineering and Materials Science, Biological Process Technology Institute, University of Minnesota, St. Paul Elastic, plastic, and hydrogel-forming protein-based pol)nners... 

Kim, S.Y. Lee, S.C. 2009, Thermo-responsive injectable hydrogel system based on poly (N-isopropylacrylamide-co-vinylphosphonic acid). I. Biomineralization and protein dehvery , Journal of Applied Polymer Science, vol. 113, pp. 3460-3469. 

Gao and designed a new hydrogel system based on A leucine zippers, but incorporating a tandem modular protein as an elastomeric mid-block. In this system, the mid-block (designated G8) is composed of eight tandem repeats of the globular... 

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