Hydrogels systems

JA Hubbell. Hydrogel systems for barriers and local drug delivery in the control of wound healing. I Controlled Release 39 305-313, 1996. 

Hybrid hydrogels are usually referred to as hydrogel systems whose components are at least two distinct classes of molecules, for example, synthetic polymers and biological macromolecules, interconnected either covalently or noncovalently. They have been of particular interest because... 

Figure 3 Schematic illustration of a hybrid hydrogel system—genetically engineered coiled-coil protein domains used to crosslink synthetic water-soluble polymers. Divalent transition metal ions are shown to form complexes with nitrogen-oxygen-donor ligands on the synthetic polymer side chains and the terminal histidine residues in the coiled coils.

Specific type of mucoadhesive compounds, like lectins, have been evaluated to solve the difficulties presented by conventional mucoadhesive hydrogel systems, for instance in the gastrointestinal route. Since these compoimds do not belong to the class of hydrogels, they are not extensively discussed here. 

H. Brpndsted, and L. Hovgaard, A novel hydrogel system designed for controlled drug delivery to the colon, Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 20 178-179 (1993). 

Properties affecting the mechanism of drug release from hydrogel systems are 1) the equilibrium water content E.W.C. which is determined by the hydrogel composition and detailed structure ... 

Broom, N.D. Oloyede, A. The importance of physicochemical swelhng in cartilage illustrated with a model hydrogel system. Biomaterials 1998,19, 1179-1188. 

Hydrogel systems containing alginates have also been investigated for delivery of proteins and peptides. ... 

Obaidat, A.A. Park, K. Characterization of glucose dependent gel-sol phase transition of the polymeric glucose-concanavalin A hydrogel system. Pharm. Res. 1996, 13, 989-995. 

Hydrogel System Monomer Feed Monomer Ratio in Copolymer" HEMA STY Precipitant Conv. % Mol. Wt. 10 Solvents... 

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